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Autor
Ambati, Aditya 1 Aran, Adi 1 Arnulf, Isabelle 1 Barateau, Lucie 1 Bassetti, Claudio L 1 Benetó, Antonio 1 Bourgin, Patrice 1 Bredahl, May Kristin Lyamouri 1 Coelho, Fernando Morgadinho 1 Crowe, Catherine 1 Dauvilliers, Yves 1 Desautels, Alex 1 Dong, Xiao Song 1 Einen, Mali 1 Eriksson, Niclas 1 Faraco, Juliette 1 Feketeova, Eva 1 Ferini-Strambi, Luigi 1 Fronczek, Rolf 1 Geisler, Peter 1
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Pracoviště
Anesthesia Critical Care and Pain Med... 1 Center for Advanced Research in Sleep... 1 Center for Applied Biomedical Researc... 1 Center for Genomic Medicine Massachus... 1 Center for Sleep Medicine and Sleep R... 1 Charité Universitätsmedizin Berlin Ei... 1 Coliseum on Majorstua Clinic Oslo Norway 1 Danish Center for Sleep Medicine Depa... 1 Department of Biology Stanford Univer... 1 Department of Biomedical Data Science... 1 Department of Biomedical and Neuromot... 1 Department of Child Psychiatry and Sl... 1 Department of Clinical Neurophysiolog... 1 Department of Clinical Neuroscience K... 1 Department of Clinical Neurosciences ... 1 Department of Epidemiology and Biosta... 1 Department of Genetics Stanford Unive... 1 Department of Human Genetics Graduate... 1 Department of Medical Sciences and Sc... 1 Department of Neurology Barcelona Spain 1
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Autor
Ambati, Aditya 1 Aran, Adi 1 Arnulf, Isabelle 1 Barateau, Lucie 1 Bassetti, Claudio L 1 Benetó, Antonio 1 Bourgin, Patrice 1 Bredahl, May Kristin Lyamouri 1 Coelho, Fernando Morgadinho 1 Crowe, Catherine 1 Dauvilliers, Yves 1 Desautels, Alex 1 Dong, Xiao Song 1 Einen, Mali 1 Eriksson, Niclas 1 Faraco, Juliette 1 Feketeova, Eva 1 Ferini-Strambi, Luigi 1 Fronczek, Rolf 1 Geisler, Peter 1
- Organizace
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Pracoviště
Anesthesia Critical Care and Pain Med... 1 Center for Advanced Research in Sleep... 1 Center for Applied Biomedical Researc... 1 Center for Genomic Medicine Massachus... 1 Center for Sleep Medicine and Sleep R... 1 Charité Universitätsmedizin Berlin Ei... 1 Coliseum on Majorstua Clinic Oslo Norway 1 Danish Center for Sleep Medicine Depa... 1 Department of Biology Stanford Univer... 1 Department of Biomedical Data Science... 1 Department of Biomedical and Neuromot... 1 Department of Child Psychiatry and Sl... 1 Department of Clinical Neurophysiolog... 1 Department of Clinical Neuroscience K... 1 Department of Clinical Neurosciences ... 1 Department of Epidemiology and Biosta... 1 Department of Genetics Stanford Unive... 1 Department of Human Genetics Graduate... 1 Department of Medical Sciences and Sc... 1 Department of Neurology Barcelona Spain 1
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Ollila, Hanna M
Autor Ollila, Hanna M Stanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
- Sharon, Eilon
- Lin, Ling
- Sinnott-Armstrong, Nasa
- Ambati, Aditya
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Yogeshwar, Selina M
Autor Yogeshwar, Selina M Stanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA Department of Neurology, Charité-Universitätsmedizin, 10117, Berlin, Germany Charité-Universitätsmedizin Berlin, Einstein Center for Neurosciences Berlin, 10117, Berlin, Germany
- Hillary, Ryan P
- Jolanki, Otto
- Faraco, Juliette
- Einen, Mali
PubMed
37188663
PubMed Central
PMC10185546
DOI
10.1038/s41467-023-36120-z
PII: 10.1038/s41467-023-36120-z
Knihovny.cz E-zdroje
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix®.
- MeSH
- autoimunita genetika MeSH
- autoimunitní nemoci * epidemiologie genetika MeSH
- chřipka lidská * epidemiologie genetika MeSH
- lidé MeSH
- narkolepsie * chemicky indukované genetika MeSH
- vakcíny proti chřipce * škodlivé účinky MeSH
- virus chřipky A, podtyp H1N1 * genetika MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Názvy látek
- vakcíny proti chřipce * MeSH
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