UV-irradiation (254 nm, 10 or 20 J/cm2) of p-aminobenzoic acid (PABA) and p-aminosalicylic acid (NaPAS) potentiated their antimutagenicity towards N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis in Salmonella typhimurium. Their inhibitory action towards the formation of the mutagen N-methyl-N-nitrosourea from the nitrosation mixture of N-methylurea and nitrite was also increased by UV-irradiation. In contrast, UV-irradiated PABA exhibited no inhibitory effects towards the mutagenicity of sodium azide or 3-azidoglycerol. Neither PABA nor NaPAS nor their UV-irradiation products were themselves mutagenic in the Ames assay.

• MeSH
• azid sodný MeSH
• azidy toxicita   MeSH
• chemická stimulace MeSH
• kyselina 4-aminobenzoová farmakologie   účinky záření   MeSH
• kyselina aminosalicylová farmakologie   účinky záření   MeSH
• methylnitronitrosoguanidin toxicita   MeSH
• methylnitrosomočovina metabolismus   MeSH
• mutace MeSH
• mutageny * MeSH
• propylenglykoly toxicita   MeSH
• Salmonella typhimurium genetika   MeSH
• ultrafialové záření * MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• azid sodný MeSH
• azidoglycerol MeSH Prohlížeč
• azidy MeSH
• kyselina 4-aminobenzoová MeSH
• kyselina aminosalicylová MeSH
• methylnitronitrosoguanidin MeSH
• methylnitrosomočovina MeSH
• mutageny * MeSH
• propylenglykoly MeSH

The azido derivatives of alcohols (3-azido-1,2-propandiol and 1,3-diazido-2-propanol) and monosaccharides (6-azido-6-deoxy-beta-D-glucose and 6-azido-6-deoxy-beta-D-galactose), as well as the proximal mutagenic product of sodium azide metabolism beta-azido-L-alanine, exhibited a high mutagenic activity in a higher plant Arabidopsis thaliana and in Salmonella typhimurium. In contrast, 11 N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines (adenine, thymine, uracil, cytosine, 2-amino-6-chloropurine, 6-chloropurine, 2,6-diaminopurine, 6-methylthiopurine, 4-O-methylthymine, 4-O-methyluracil and 7-deaza-8-azaadenine) were mutagenic in the Ames assay but ineffective in the Arabidopsis mutagenicity assay.

• MeSH
• 1-propanol toxicita   MeSH
• alanin analogy a deriváty   toxicita   MeSH
• alkoholy toxicita   MeSH
• azidy toxicita   MeSH
• deoxyglukosa analogy a deriváty   toxicita   MeSH
• fukosa analogy a deriváty   toxicita   MeSH
• monosacharidy toxicita   MeSH
• mutace * MeSH
• propylenglykoly toxicita   MeSH
• puriny toxicita   MeSH
• pyrimidiny toxicita   MeSH
• rostliny genetika   MeSH
• Salmonella typhimurium genetika   MeSH
• testy genotoxicity * MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• 1-propanol MeSH
• alanin MeSH
• alkoholy MeSH
• azidoalanine MeSH Prohlížeč
• azidy MeSH
• deoxyglukosa MeSH
• fukosa MeSH
• monosacharidy MeSH
• propylenglykoly MeSH
• puriny MeSH
• pyrimidiny MeSH

Nitrosation of the carbamate insecticide propoxur at pH 3 and 37 degrees C was determined colorimetrically and found to be time- and sodium nitrite concentration-dependent. Nitrosated propoxur was mutagenic when exposed to the seeds of the higher plant Arabidopsis thaliana but the formation of nitrosopropoxur, the presumed mutagen, was inhibited by humic acids, para-aminobenzoic acid and ascorbic acid. These agents also reduced the mutagenicity of preformed nitrosopropoxur.

• MeSH
• huminové látky farmakologie   MeSH
• kyselina 4-aminobenzoová farmakologie   MeSH
• kyselina askorbová farmakologie   MeSH
• mutageny * metabolismus   MeSH
• nitrosace MeSH
• propoxur analogy a deriváty   metabolismus   toxicita   MeSH
• rostliny účinky léků   genetika   MeSH
• testy genotoxicity MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• huminové látky MeSH
• kyselina 4-aminobenzoová MeSH
• kyselina askorbová MeSH
• mutageny * MeSH
• N-nitrosopropoxur MeSH Prohlížeč
• propoxur MeSH