The mutagenicity of azido derivatives of monosaccharides and alcohols and of N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines in Arabidopsis thaliana and in Salmonella typhimurium
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články
PubMed
2038273
DOI
10.1093/mutage/6.1.55
Knihovny.cz E-zdroje
- MeSH
- 1-propanol toxicita MeSH
- alanin analogy a deriváty toxicita MeSH
- alkoholy toxicita MeSH
- azidy toxicita MeSH
- deoxyglukosa analogy a deriváty toxicita MeSH
- fukosa analogy a deriváty toxicita MeSH
- monosacharidy toxicita MeSH
- mutace * MeSH
- propylenglykoly toxicita MeSH
- puriny toxicita MeSH
- pyrimidiny toxicita MeSH
- rostliny genetika MeSH
- Salmonella typhimurium genetika MeSH
- testy genotoxicity * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 1-propanol MeSH
- alanin MeSH
- alkoholy MeSH
- azidoalanine MeSH Prohlížeč
- azidy MeSH
- deoxyglukosa MeSH
- fukosa MeSH
- monosacharidy MeSH
- propylenglykoly MeSH
- puriny MeSH
- pyrimidiny MeSH
The azido derivatives of alcohols (3-azido-1,2-propandiol and 1,3-diazido-2-propanol) and monosaccharides (6-azido-6-deoxy-beta-D-glucose and 6-azido-6-deoxy-beta-D-galactose), as well as the proximal mutagenic product of sodium azide metabolism beta-azido-L-alanine, exhibited a high mutagenic activity in a higher plant Arabidopsis thaliana and in Salmonella typhimurium. In contrast, 11 N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines (adenine, thymine, uracil, cytosine, 2-amino-6-chloropurine, 6-chloropurine, 2,6-diaminopurine, 6-methylthiopurine, 4-O-methylthymine, 4-O-methyluracil and 7-deaza-8-azaadenine) were mutagenic in the Ames assay but ineffective in the Arabidopsis mutagenicity assay.
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