The mutagenicity of azido derivatives of monosaccharides and alcohols and of N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines in Arabidopsis thaliana and in Salmonella typhimurium
Language English Country England, Great Britain Media print
Document type Journal Article
PubMed
2038273
DOI
10.1093/mutage/6.1.55
Knihovny.cz E-resources
- MeSH
- 1-Propanol toxicity MeSH
- Alanine analogs & derivatives toxicity MeSH
- Alcohols toxicity MeSH
- Azides toxicity MeSH
- Deoxyglucose analogs & derivatives toxicity MeSH
- Fucose analogs & derivatives toxicity MeSH
- Monosaccharides toxicity MeSH
- Mutation * MeSH
- Propylene Glycols toxicity MeSH
- Purines toxicity MeSH
- Pyrimidines toxicity MeSH
- Plants genetics MeSH
- Salmonella typhimurium genetics MeSH
- Mutagenicity Tests * MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- 1-Propanol MeSH
- Alanine MeSH
- Alcohols MeSH
- azidoalanine MeSH Browser
- Azides MeSH
- Deoxyglucose MeSH
- Fucose MeSH
- Monosaccharides MeSH
- Propylene Glycols MeSH
- Purines MeSH
- Pyrimidines MeSH
The azido derivatives of alcohols (3-azido-1,2-propandiol and 1,3-diazido-2-propanol) and monosaccharides (6-azido-6-deoxy-beta-D-glucose and 6-azido-6-deoxy-beta-D-galactose), as well as the proximal mutagenic product of sodium azide metabolism beta-azido-L-alanine, exhibited a high mutagenic activity in a higher plant Arabidopsis thaliana and in Salmonella typhimurium. In contrast, 11 N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines (adenine, thymine, uracil, cytosine, 2-amino-6-chloropurine, 6-chloropurine, 2,6-diaminopurine, 6-methylthiopurine, 4-O-methylthymine, 4-O-methyluracil and 7-deaza-8-azaadenine) were mutagenic in the Ames assay but ineffective in the Arabidopsis mutagenicity assay.
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