Electrocardiography is one of most classical methods of examination in medicine and in cardiology. After more than 100 years of practical use, it is indispensable in diagnosing arrhythmias as well as several, clinically important proarrhythmic states. In those, the heart with normal anatomy endangers the patient with the risk of serious, frequently life threatening arrhythmias (Long QT Syndrome, Brugada Syndrome, Wolff-Parkinson-White Syndrome, T-wave alternans). Further, electrocardiography is nowadays important in diagnosing the very fresh signs of myocardial ischemia. Present time electrocardiography is demanding for manufacturers of electrocardiographic machines, and requires precise, standard technique of examination. Despite automatic evaluation programmes of electrocardiogram, which are nowadays almost a standard, physicians should understand well the electrocardiogram, and must be able to correct frequent inaccuracies of the automatic evaluations.

• MeSH
• elektrokardiografie * MeSH
• kardiomegalie diagnóza   MeSH
• lidé MeSH
• srdeční arytmie diagnóza   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

• MeSH
• angina pectoris farmakoterapie   metabolismus   MeSH
• energetický metabolismus MeSH
• lidé MeSH
• myokard metabolismus   MeSH
• trimetazidin terapeutické užití   MeSH
• vazodilatancia terapeutické užití   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• komentáře MeSH
• úvodníky MeSH
• Názvy látek
• trimetazidin MeSH
• vazodilatancia MeSH

This study aims to assess the efficacy and tolerance of the metabolic antianginal agent trimetazidine, a 3-KAT inhibitor, in 141 stable angina patients aged 65-86 years. Efficacy was assessed with exercise tests and clinical evaluation after 12 weeks of treatment. The main outcome was an increase in exercise duration by 52 +/- 92 sec (p < 0.001). Other exercise test parameters also improved, with no change in rate-pressure product. Angina attacks and short-acting nitrate consumption significantly decreased, indicating an improvement in quality of life. Two adverse events were reported (gastric pain and dyspepsia) but they were mild and transient. In conclusion, in elderly stable angina patients, trimetazidine improves exercise stress tests and angina symptoms. Because of its metabolic effect, free from any haemodynamic action, trimetazidine proved to be beneficial in elderly patients and with an excellent tolerance profile.

• MeSH
• angina pectoris farmakoterapie   MeSH
• hodnocení léčiv MeSH
• lidé MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• terapie cvičením MeSH
• trimetazidin terapeutické užití   MeSH
• vazodilatancia terapeutické užití   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• Názvy látek
• trimetazidin MeSH
• vazodilatancia MeSH

• MeSH
• elektrokardiografie * MeSH
• lidé MeSH
• srdeční arytmie diagnóza   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• biologické markery krev   MeSH
• diferenciální diagnóza MeSH
• dysfunkce levé srdeční komory komplikace   diagnóza   MeSH
• dyspnoe etiologie   MeSH
• lidé MeSH
• natriuretický peptid typu B MeSH
• nemoci srdce komplikace   diagnóza   MeSH
• peptidové fragmenty krev   MeSH
• proteinové prekurzory krev   MeSH
• proteiny nervové tkáně krev   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• komentáře MeSH
• úvodníky MeSH
• Názvy látek
• biologické markery MeSH
• natriuretický peptid typu B MeSH
• peptidové fragmenty MeSH
• pro-brain natriuretic peptide (1-76) MeSH Prohlížeč
• proteinové prekurzory MeSH
• proteiny nervové tkáně MeSH

• MeSH
• dějiny 20. století MeSH
• elektrokardiografie dějiny   trendy   MeSH
• lidé MeSH
• Check Tag
• dějiny 20. století MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• historické články MeSH

Female phenotype, sexual infantilism, small stature and stigmatization are typical for patients with Turner's syndrome (TS). The most frequent cardiovascular manifestations in these patients are a bicuspidal aortal valve and coarctation of the aorta. In 5% patients dilatation of the aorta is found which can develop into a dissecting aneurysm. In the submitted case-history the authors describe a 34-year-old patient where the diagnosis of TS was proved only in adult age at the time when a dissecting aneurysm of the aorta was detected. The submitted case-history supports the recommendation of regular echocardiographic check-up examinations of patients with TS.

• MeSH
• aortální aneurysma komplikace   diagnostické zobrazování   MeSH
• disekce aorty komplikace   diagnostické zobrazování   MeSH
• dospělí MeSH
• lidé MeSH
• Turnerův syndrom komplikace   MeSH
• ultrasonografie MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

There was studied the effect of intravenously administered creatin phosphate (Neoton-drug with cardioprotective effect, Alfa Schiapparelli Wassermann) in the group of 98 patients affected by their first attack of myocardial infarction. In the course of the treatment there were observed the serum level of many biochemical indices, including the cardioselective enzyme activity. We concluded that the patients treated with Neoton, compared with the control group, revealed the significantly higher elevation of the CK, AST and LDH activity levels and the shift of the CK peak activity towards to the earlier hours after the onset of anginal pain.

• MeSH
• fibrinolytika terapeutické užití   MeSH
• fosfokreatin terapeutické užití   MeSH
• infarkt myokardu farmakoterapie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky, fáze II MeSH
• klinické zkoušky MeSH
• multicentrická studie MeSH
• Názvy látek
• fibrinolytika MeSH
• fosfokreatin MeSH

BACKGROUND: The value of operation of atrial septal defect (ASD) in adults, especially after 40 years, is still discussed. METHODS AND RESULTS: In 1994-95 57 adults with unoperated ASD were examined clinically, echocardiographically and in 75% by catheterization. Type primum was present in 11%, type secundum in 77% and sinus venosus in 11%. Group A comprised 28 patients aged 20 to 40 years (average 29), group B comprised 29 patients aged 40 to 62 years (average 51). The groups (B:A) did not differ in pulmonary to systemic flow (Qp/Qs) (2.4:2.2) or pulmonary arteriolar resistance (PAR) (group B 2 U.m2, group A 1.7 U.m2), the older patients had worse New York Heart Association (NYHA) classification, more frequent tricuspid regurgitation (group B 96%, group A 45%), significantly larger right ventricles and pulmonary arteries, higher mean pulmonary artery pressure (group B 26 mmHg, group A 17 mmHg) and right ventricle end-diastolic pressure (RVEDP group B 10, group A 8.8 mmHg). All defects larger than 10 mm by transesophageal echocardiography (TEE) had Qp/Qs 1.5 or more. Forty patients were operated with zero mortality, in three cases by minithoracothomy. Postoperatively, 50% of group A and 63% of group B felt better, NYHA classification was significantly better in both groups. Tricuspid regurgitation decreased in both groups as well as the size of right ventricle. The size of the left ventricle enlarged after operation in group A. CONCLUSION: This study suggests to operate adults with ASD larger than 10 mm by TEE with signs of right ventricle overload and/or Qp/Qs 1.5 or more, who have normal PAR. Operative mortality was zero in both age groups, the functional repair was better in younger patients (under 40 years).

• MeSH
• defekty septa síní patofyziologie   chirurgie   MeSH
• dospělí MeSH
• echokardiografie transezofageální MeSH
• elektrokardiografie MeSH
• lidé středního věku MeSH
• lidé MeSH
• pooperační komplikace MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Intensive research into the presence of endogenous digitalis-like factor (EDLF) started shortly after identification of the alpha subunit of the Na,K,-ATPase as being receptor for digitalis glycosides. After years of skepticism, present data testify EDLF really exists. Most probably, the EDLF has chemical structure of either ouabain or of one of its isomers. It is secreted by the adrenal cortex, and, under conditions of stress, it's secretion is regulated differently from the secretion of both gluco- and mineralocorticoids. The physiological role of the EDLF has not been fully understood yet. In the newborn's kidneys, the inhibition of the Na,K-ATPase may assist to increase elimination of surplus sodium from the organism. In individuals of any age, the inhibitory influence of EDLF upon Na,K-ATPase in the arterial wall smooth muscle cells increases peripheral vascular resistance and thus, blood pressure. In the tissue culture, direct positive inotropic influences of EDLF upon rat cardiomyocytes was observed. However, the importance of positive inotropic effect of the EDLF upon the heart in clinical medicine remains to be elucidated.

• MeSH
• chemické jevy MeSH
• chemie MeSH
• digoxin * MeSH
• inhibitory enzymů chemie   metabolismus   MeSH
• kardenolidy MeSH
• krysa rodu Rattus MeSH
• lidé MeSH
• saponiny chemie   metabolismus   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• digoxin-like factors MeSH Prohlížeč
• digoxin * MeSH
• inhibitory enzymů MeSH
• kardenolidy MeSH
• saponiny MeSH