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Autor
Alfonzo, Juan 1 Aphasizhev, Ruslan 1 Aphasizheva, Inna 1 Carnes, Jason 1 Cestari, Igor 1 Cruz-Reyes, Jorge 1 Göringer, H Ulrich 1 Hajduk, Stephen 1 Lukeš, Julius 1 Madison-Antenucci, Susan 1 Maslov, Dmitri A 1 McDermott, Suzanne M 1 Ochsenreiter, Torsten 1 Read, Laurie K 1 Salavati, Reza 1 Schnaufer, Achim 1 Schneider, André 1 Simpson, Larry 1 Stuart, Kenneth 1 Yurchenko, Vyacheslav 1
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Pracoviště
Center for Global Infectious Disease ... 1 Department of Biochemistry and Biophy... 1 Department of Biochemistry and Molecu... 1 Department of Chemistry and Biochemis... 1 Department of Microbiology Immunology... 1 Department of Microbiology The Ohio S... 1 Department of Microbiology and Immuno... 1 Department of Molecular Cell and Syst... 1 Department of Molecular Genetics Darm... 1 Department of Molecular and Cell Biol... 1 Institute of Cell Biology University ... 1 Institute of Immunology and Infection... 1 Institute of Parasitology Biology Cen... 1 Institute of Parasitology McGill Univ... 1 Life Science Research Centre Faculty ... 1 Parasitology Laboratory Wadsworth Cen... 1 School of Life Science and Technology... 1 University of Minnesota Medical Schoo... 1
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Autor
Alfonzo, Juan 1 Aphasizhev, Ruslan 1 Aphasizheva, Inna 1 Carnes, Jason 1 Cestari, Igor 1 Cruz-Reyes, Jorge 1 Göringer, H Ulrich 1 Hajduk, Stephen 1 Lukeš, Julius 1 Madison-Antenucci, Susan 1 Maslov, Dmitri A 1 McDermott, Suzanne M 1 Ochsenreiter, Torsten 1 Read, Laurie K 1 Salavati, Reza 1 Schnaufer, Achim 1 Schneider, André 1 Simpson, Larry 1 Stuart, Kenneth 1 Yurchenko, Vyacheslav 1
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Pracoviště
Center for Global Infectious Disease ... 1 Department of Biochemistry and Biophy... 1 Department of Biochemistry and Molecu... 1 Department of Chemistry and Biochemis... 1 Department of Microbiology Immunology... 1 Department of Microbiology The Ohio S... 1 Department of Microbiology and Immuno... 1 Department of Molecular Cell and Syst... 1 Department of Molecular Genetics Darm... 1 Department of Molecular and Cell Biol... 1 Institute of Cell Biology University ... 1 Institute of Immunology and Infection... 1 Institute of Parasitology Biology Cen... 1 Institute of Parasitology McGill Univ... 1 Life Science Research Centre Faculty ... 1 Parasitology Laboratory Wadsworth Cen... 1 School of Life Science and Technology... 1 University of Minnesota Medical Schoo... 1
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- Země - grant
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PubMed
32191849
PubMed Central
PMC7083771
DOI
10.1016/j.pt.2020.01.006
PII: S1471-4922(20)30016-7
Knihovny.cz E-zdroje
Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.
- Klíčová slova
- RNA decay, RNA editing, Trypanosoma, kinetoplast, mitochondria, polyadenylation,
- MeSH
- editace RNA fyziologie MeSH
- RNA mitochondriální genetika metabolismus MeSH
- RNA protozoální genetika metabolismus MeSH
- Trypanosoma brucei brucei genetika metabolismus MeSH
- zvířata MeSH
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- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
- Názvy látek
- RNA mitochondriální MeSH
- RNA protozoální MeSH
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