BACKGROUND: Childhood narcolepsy is associated with various emotional, behavioural and cognitive dysfunctions as well as with psychiatric and neurodevelopmental disorders: anxiety, depression, attention deficit hyperactivity disorder and psychosis. A relationship between these conditions is unclear - comorbidity or similar pathophysiological mechanisms can be suggested. OBJECTIVE: We reported four children with narcolepsy type 1 (NT1) and autism spectrum disorder (ASD) - Asperger syndrome (AS). RESULTS AND CONCLUSION: To the best of our knowledge co-occurrence of NT1 and AS has not been described in the literature as noted in this report.

• Klíčová slova
• Asperger syndrome, Autism spectrum disorders, Comorbidity, Hypocretin, Narcolepsy type 1,
• MeSH
• antidepresiva terapeutické užití   MeSH
• Aspergerův syndrom diagnóza   MeSH
• deprese diagnóza   farmakoterapie   MeSH
• dítě MeSH
• hyperkinetická porucha diagnóza   MeSH
• komorbidita * MeSH
• lidé MeSH
• methylfenidát aplikace a dávkování   MeSH
• narkolepsie komplikace   MeSH
• poruchy nadměrné spavosti diagnóza   farmakoterapie   MeSH
• stadia spánku fyziologie   MeSH
• tikové poruchy diagnóza   MeSH
• úzkostné poruchy diagnóza   farmakoterapie   MeSH
• věk při počátku nemoci * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antidepresiva MeSH
• methylfenidát MeSH

The aim of our study was to examine odor detection thresholds and odor identification in autistic subjects. Thirty-five patients with Asperger's syndrome and high functioning autism (mean age 10.8 ± 3.6 years; 31 boys) were compared with 35 healthy control subjects (mean age 10.4 ± 2.4 years; 28 boys). There were no significant differences between groups with regard to mean age (p = 0.598) and gender proportion (p = 0.324). Olfactory testing used the Sniffin' Sticks test (threshold and identification parts only). Participants with Asperger's syndrome and high functioning autism, in comparison with healthy controls, were significantly impaired relative to odor detection thresholds (6.3 ± 3.1 vs. 7.9 ± 2.0; p = 0.025). Autistic participants were significantly better in correctly identifying the odor of an orange (94 vs. 63%; p < 0.05) and significantly worse at correctly identifying the odor of cloves (40 vs. 74%; p < 0.05). With regard to identification of fourteen other substances, there were no significant differences. There was no significant difference between autistic and control subjects on the total score of olfactory identification (p = 0.799). Odor identification ability (as expressed by this total score) correlated significantly with age in the control group (p = 0.049), but not in the autism group (p = 0.103). We found impaired odor detection and almost normal odor identification in children with autism. Implications for further research are discussed.

• MeSH
• Aspergerův syndrom * komplikace   patofyziologie   MeSH
• autistická porucha * komplikace   patofyziologie   MeSH
• čich * MeSH
• čichová percepce * MeSH
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• odoranty MeSH
• poruchy čichu * etiologie   patofyziologie   MeSH
• psychiatrické posuzovací škály MeSH
• senzorické prahy MeSH
• stupeň závažnosti nemoci MeSH
• věkové faktory MeSH
• výběr pacientů MeSH
• výzkumný projekt MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH