OBJECTIVES: To determine the prevalence and distribution of US-detected qualitative cartilage damage at metacarpal heads of patients with RA and hand OA. METHODS: Fifty-two RA patients and 34 patients with hand OA were enrolled. US examination of the metacarpal head cartilage from the II to V finger of both hands was performed. A total of 414 MCP joints in RA and 266 MCP joints in OA patients were scanned with a linear probe up to 22 MHz. Qualitative assessments using a previously described scoring system for cartilage damage were performed. The prevalence and distribution of cartilage damage were analysed. Multivariate regression analysis was used to determine the predictive value of age, gender, BMI, disease duration and the presence of RF and anti-CCP antibodies for US-detected cartilage damage. RESULTS: The metacarpal head cartilage was positive for cartilage damage in 35.7% (148/414) of MCP joints in RA and in 43.6% (116/266) of MCP joints in OA patients. In RA, the hyaline cartilage of the II and III metacarpal heads (bilaterally) was the most frequently affected. In OA, cartilage damage was more homogeneously distributed in all MCP joints. Multivariate regression analysis showed that age and disease duration, but not gender, BMI or autoantibody status, were independent predictors of US-detected cartilage damage in RA. CONCLUSION: Cartilage damage was found in more than one-third of the MCP joints in both RA and OA patients, and in RA patients, the II and III MCP joints were the most damaged.

• Klíčová slova
• OA, RA, cartilage damage, ultrasonography,
• MeSH
• antirevmatika terapeutické užití   MeSH
• autoprotilátky krev   MeSH
• dospělí MeSH
• kloubní chrupavka diagnostické zobrazování   MeSH
• lidé středního věku MeSH
• lidé MeSH
• metakarpofalangeální kloub diagnostické zobrazování   MeSH
• nemoci chrupavky diagnostické zobrazování   etiologie   MeSH
• osteoartróza komplikace   diagnostické zobrazování   farmakoterapie   MeSH
• radiografie MeSH
• reprodukovatelnost výsledků MeSH
• revmatoidní artritida komplikace   diagnostické zobrazování   farmakoterapie   MeSH
• senioři MeSH
• sexuální faktory MeSH
• stupeň závažnosti nemoci MeSH
• ultrasonografie MeSH
• věkové faktory MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antirevmatika MeSH
• autoprotilátky MeSH