To evaluate vitamin D levels in children treated with fractures during the healing period. A four-year prospective study, including healthy children treated with diaphyseal fracture of femur or forearm bones. Vitamin D levels were examined four times: at the time of the injury and then one, three, and five months after the injury, together with P1NP, ALP, GGT, and parathormone. In the beginning, patients were blindly divided into two groups, one supplemented with vitamin D3 for the entire follow-up period, the other non-supplemented. Altogether, 107 children underwent examination at the time of their injuries. Of these, 63 were included in the study and examined for the entire follow-up period - 36 supplemented, 27 non-supplemented. At the time of injury, 42 % had a deficit of vitamin D, 36.5 % had insufficiency, only 21.5 % had normal levels. In the children supplemented with cholecalciferol, vitamin D levels increased statistically significantly during the follow-up period (already after 1 month), in contrast with non-supplemented patients, where they did not. When we divided patients according to the initial vitamin D levels (deficit/insufficiency/normal levels) or fracture type (femur/forearm), we also observed significantly better results in supplemented groups. We observed a high prevalence of vitamin D deficit or insufficiency in healthy children at the time of their injuries. Patients supplemented with vitamin D3 had normal levels already after one month and this persisted throughout the follow-up period, in contrast with non-supplemented patients. Therefore, we recommend vitamin D testing and administration for children treated for fractures. Keywords: Vitamin D, Pediatric fracture, Children, Vitamin D supplementation.

• MeSH
• cholekalciferol krev   terapeutické užití   MeSH
• dítě MeSH
• fraktury femuru krev   epidemiologie   MeSH
• hojení fraktur * účinky léků   MeSH
• lidé MeSH
• mladiství MeSH
• následné studie MeSH
• nedostatek vitaminu D * krev   epidemiologie   farmakoterapie   MeSH
• potravní doplňky MeSH
• předškolní dítě MeSH
• prospektivní studie MeSH
• vitamin D * krev   terapeutické užití   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• cholekalciferol MeSH
• vitamin D * MeSH

PURPOSE OF THE STUDY: The aim of this study was to determine the changes in total antioxidant capacity (TAC) during the fracture healing process. MATERIAL AND METHODS: Twenty patients with isolated closed femoral fracture, between the ages 18 and 60 years, were included in the study. The control group was formed with healthy volunteers. Venous blood was drawn from the healthy volunteers once, and from the patients five times during 14 days after fracture. TAC was measured in the sera of these samples. RESULTS: In the patient group, the serum TAC was the highest in the first 6 hours, whereas there was a decreasing trend on the 3rd, 7th and 14th days, and an increasing trend on the 5th day. The mean serum TAC in all measurements of the patient group were lower than those in the control group. CONCLUSION: The present study suggests that TAC may be decreased in considerable amounts during the first 2 weeks of fracture healing.

• MeSH
• antioxidancia metabolismus   terapeutické užití   MeSH
• dospělí MeSH
• fraktury femuru krev   farmakoterapie   MeSH
• hojení fraktur fyziologie   MeSH
• ischemie metabolismus   MeSH
• lidé středního věku MeSH
• lidé MeSH
• malondialdehyd metabolismus   MeSH
• oxidační stres fyziologie   MeSH
• prospektivní studie MeSH
• reaktivní formy kyslíku krev   MeSH
• studie případů a kontrol MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antioxidancia MeSH
• malondialdehyd MeSH
• reaktivní formy kyslíku MeSH