It is known that macrophages release into medium in vitro biologically active substances which modulate immune response. In recent years, increase attention has been directed towards the role of prostaglandin in macrophage function. Guinea pig splenic lymphocytes and peritoneal macrophage cultures were incubated with quartz (DQ12), Corundum and aspirin as prostaglandin inhibitor. Lymphocyte proliferation measured by 3H-thymidine incorporation, and lymphokine release by Bendixen-Soborg capillary test (MIF) were applied. EA rosetting and phagocytosis were determined for macrophage function assessment. Quartz suppressed the immune response evidenced by reduced 3H-thymidine incorporation and decreased lymphokine production. Aspirin (as a specific prostaglandin synthesis inhibitor) restored the affected by quartz immunological parameters. This observation gives support to the hypothesis that the immunological response to quartz involves macrophage prostaglandin release, presumably as a first step of lipid peroxidation.
- MeSH
- aktivace lymfocytů účinky léků MeSH
- aktivace makrofágů účinky léků MeSH
- buněčná imunita účinky léků MeSH
- imunosupresivní léčba MeSH
- inhibiční faktory migrace makrofágů metabolismus MeSH
- křemen farmakologie MeSH
- makrofágy účinky léků imunologie MeSH
- morčata MeSH
- oxid křemičitý farmakologie MeSH
- prostaglandiny imunologie MeSH
- T-lymfocyty účinky léků imunologie MeSH
- techniky in vitro MeSH
- zvířata MeSH
- Check Tag
- morčata MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- inhibiční faktory migrace makrofágů MeSH
- křemen MeSH
- oxid křemičitý MeSH
- prostaglandiny MeSH
- Klíčová slova
- METABOLISM, TISSUE *, QUARTZ/effects *,
- MeSH
- křemen farmakologie MeSH
- lidé MeSH
- metabolismus * MeSH
- prach * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- křemen MeSH
- prach * MeSH
