The phagocytic activity of leukocytes in peripheral blood was investigated after 2, 24, and 48 hr; 1, 2, 4, and 8 weeks; and 6 and 12 months following intraperitoneal administration of asbestos and basalt fibers to Wistar rats. Asbestos and basalt fibers differed in their effects on the parameters studied. Both granulocyte count and phagocytic activity of leukocytes during the 1-year dynamic follow-up in both dust-exposed groups of animals changed in two phases, characterized by the initial stimulation of the acute phase I, followed by the suppression of the parameters in the chronic phase II. Exposure to asbestos and basalt fibers led, in phase II, to impairment of the phagocytic activity of granulocytes. Asbestos fibers also significantly decreased phagocytic activity of monocytes. Exposure to basalt fibers did not affect the phagocytic activity of monocytes in phase II. Results suggest that the monocytic component of leukocytes plays an important role in the development of diseases caused by exposure to fibrous dusts, but basalt fibers have lesser biological effects than asbestos fibers.

• MeSH
• chrysotilový azbest toxicita   MeSH
• fagocytóza fyziologie   MeSH
• granulocyty imunologie   MeSH
• krysa rodu Rattus MeSH
• leukocyty imunologie   MeSH
• minerály toxicita   MeSH
• monocyty imunologie   MeSH
• následné studie MeSH
• potkani Wistar MeSH
• prach MeSH
• silikáty toxicita   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• basalt MeSH Prohlížeč
• chrysotilový azbest MeSH
• minerály MeSH
• prach MeSH
• silikáty MeSH