INTRODUCTION: This was a single-center pilot study that sought to describe an innovative use of 4DryField® PH (premix) for preventing the recurrence of intrauterine adhesions (IUAs) after hysteroscopic adhesiolysis in patients with Asherman's syndrome (AS). MATERIAL AND METHODS: Twenty-three patients with AS were enrolled and 20 were randomized (1:1 ratio) to intrauterine application of 4DryField® PH (n = 10) or Hyalobarrier® gel (n = 10) in a single-blind manner. We evaluated IUAs (American Fertility Society [AFS] score) during initial hysteroscopy and second-look hysteroscopy one month later. Patients completed a follow-up symptoms questionnaire three and reproductive outcomes questionnaire six months later. RESULTS: The demographic and clinical characteristics, as well as severity of IUAs, were comparable in both groups. The mean initial AFS score was 9 and 8.5 in the 4DryField® PH and Hyalobarrier® gel groups, respectively (p = .476). There were no between-group differences in AFS progress (5.9 vs. 5.6, p = .675), need for secondary adhesiolysis (7 vs. 7 patients, p = 1), and the follow-up outcomes. CONCLUSION: 4DryField® PH could be a promising antiadhesive agent for preventing the recurrence of IUAs, showing similar effectiveness and safety to Hyalobarrier® gel. Our findings warrant prospective validation in a larger clinical trial. CLINICAL TRIAL REGISTRY NUMBER: ISRCTN15630617.

• Klíčová slova
• Asherman’s syndrome, Prevention of intrauterine adhesions, hyaluronan gel, hysteroscopic adhesiolysis, modified starch,
• MeSH
• adheze tkání prevence a kontrola   MeSH
• dospělí MeSH
• gely MeSH
• gynatrézie * chirurgie   MeSH
• hysteroskopie * metody   MeSH
• jednoduchá slepá metoda MeSH
• kyselina hyaluronová * aplikace a dávkování   MeSH
• lidé MeSH
• nemoci dělohy * prevence a kontrola   MeSH
• pilotní projekty MeSH
• průzkumy a dotazníky MeSH
• recidiva MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• randomizované kontrolované studie MeSH
• srovnávací studie MeSH
• Názvy látek
• gely MeSH
• kyselina hyaluronová * MeSH

• MeSH
• hysterektomie * MeSH
• lidé MeSH
• nemoci dělohy prevence a kontrola   MeSH
• píštěle prevence a kontrola   MeSH
• vaginální píštěl prevence a kontrola   MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH