Histological examination of 38 nodular formations extirpated from the site of vaccine administration to cats disclosed 25 cases of sarcoma and 13 of granuloma. Average age of the cats bearing sarcoma was 8.75 years whereas granuloma occurred at average age of 1.9 year. This age-relationship of the lesions, as well as their similar morphologic features indicated a progression of chronic inflammatory changes to tumors. Similar tumors were diagnosed in one cat with "posttraumatic ocular sarcoma" and in the uterus of female-cat with long-standing pyometra. These two cats were 15 and 8 years old, respectively. Experimental study of local reaction 21 days after administration of commercial, lipid-adjuvanted vaccine revealed in young cats (age 9 months) a reaction to immunogen, whereas in old animals (age 10 to 15 years) there was a reaction to foreign material. The data suggest that chronic inflammation and age-related immunodeficiency are instrumental in pathogenesis of the vaccine-associated sarcoma.
- MeSH
- alkalická fosfatasa analýza MeSH
- imunoenzymatické techniky veterinární MeSH
- imunokompromitovaný pacient MeSH
- karboxylesterasa analýza MeSH
- kočky MeSH
- kyselá fosfatasa analýza MeSH
- nádory měkkých tkání enzymologie etiologie patologie veterinární MeSH
- nemoci koček patologie MeSH
- sarkom enzymologie etiologie patologie veterinární MeSH
- vakcinace škodlivé účinky veterinární MeSH
- zánět komplikace enzymologie patologie veterinární MeSH
- zvířata MeSH
- Check Tag
- kočky MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- alkalická fosfatasa MeSH
- karboxylesterasa MeSH
- kyselá fosfatasa MeSH
