The prevalence of hepatitis G virus (HGV) in the serum of intravenous immunoglobulin (IVIG) recipients was studied and risk related to HGV positivity was considered. Although its pathogenicity is unclear, HGV is likely to cause liver disease or lymphoproliferation. Twenty (23%) of 86 tested MG patients were HGV RNA positive. Of the HGV positive patients, three (15%) showed mild elevation of liver enzymes and one (5%) was diagnosed with chronic lymphatic leukaemia prior to the institution of MG replacement. It can be concluded that the HGV prevalence among IVIG recipients is high but is not associated with signs of either liver disease or lymphoproliferation.

• MeSH
• intravenózní imunoglobuliny škodlivé účinky   terapeutické užití   MeSH
• lidé MeSH
• prevalence MeSH
• sérologické testy MeSH
• syndromy imunologické nedostatečnosti farmakoterapie   MeSH
• virová hepatitida u lidí diagnóza   epidemiologie   virologie   MeSH
• virus GB-C izolace a purifikace   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Názvy látek
• intravenózní imunoglobuliny MeSH

Prevalence of HGV(GBV-C) infection and its coinfection with HBV a HCV infections were studied in group of 82 haemodialysis patients. This study was realized 20 months latter again -- 16 patients from 82 were running in dialysis, 17 patients were transplanted and 49 patients died (non of this viruses was cause of their death). HGV(GBV-C) RNA was detected in serum of 22 patients, 20 months latter it was detected in serum of 3 patients; one positive was new. 20 months latter any HGV(GBV-C) RNA was not detected in serum of 4 originally positive patients. Three of ten HBsAg positive patients were coinfected by HGV(GBV-C) RNA; 20 months latter any coinfection was found. In the first we found HGV(GBV-C) RNA in serum of 5 anti-HCV positive patients and in serum of 1 HCV RNA positive patient; 20 months latter it was in serum of 1 and 1 respectively. Elevation of ALT and AST levels were found in serum of 3 from 82 patients; two patients were coinfected with HBV or HCV. Any from 2 running dialysis patients with elevation of ALT and AST levels was not HGV(GBV-C) RNA positive. This virus is not probably frequent cause of liver disease in dialysis patients and it is not necessary to routinely screen for HGV(GBV-C) infection in this group of patients.

• MeSH
• dialýza ledvin * MeSH
• dospělí MeSH
• hepatitida B komplikace   diagnóza   MeSH
• hepatitida C komplikace   diagnóza   MeSH
• infekce viry z čeledi Flaviviridae komplikace   diagnóza   MeSH
• lidé středního věku MeSH
• lidé MeSH
• RNA virová analýza   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• sérologické testy MeSH
• virová hepatitida u lidí komplikace   diagnóza   MeSH
• virus GB-C * izolace a purifikace   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• RNA virová MeSH

The group of infectious agents causing viral hepatitis was extended by another virus the detection of which was published in 1995. This virus is described as virus of hepatitis G (HGV) or GBV-C virus and is included among RNA viruses family Flaviviridae. Detection of HGV is based on reverse transcription with subsequent amplification of the viral nucleic acid by means of a polymerase chain reaction. The authors examined sera of 82 chronically haemodialyzed patients incl. 22 (26.8%) HGV RNA positive ones, whereby coinfection with HBV was proved in 3 specimens (13%). In 6 HGV RNA positive samples anti-HCV positivity was found (27%), incl. one sample where HCV RNA positivity was proved (4.5%). Raised transaminase activity was found only in three patients with HGV RNA positivity (13.6%). From the presented results ensues that haemodialyzed patients are a high risk group for HGV infection.

• MeSH
• dialýza ledvin škodlivé účinky   MeSH
• hepatitida B komplikace   diagnóza   epidemiologie   MeSH
• hepatitida C komplikace   diagnóza   epidemiologie   MeSH
• infekce viry z čeledi Flaviviridae komplikace   diagnóza   epidemiologie   MeSH
• lidé MeSH
• rizikové faktory MeSH
• RNA virová krev   MeSH
• séroepidemiologické studie MeSH
• virová hepatitida u lidí epidemiologie   etiologie   MeSH
• virus GB-C * izolace a purifikace   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• RNA virová MeSH