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Autor
Ahn, Yoon-Ok 1 Arndt, Volker 1 Berndt, Sonja I 1 Bishop, D Timothy 1 Brenner, Hermann 1 Brezina, Stefanie 1 Buchanan, Daniel D 1 Bujanda, Luis 1 Burnett-Hartman, Andrea 1 Cai, Qiuyin 1 Campbell, Peter T 1 Carreras-Torres, Robert 1 Casey, Graham 1 Castellví-Bel, Sergi 1 Chan, Andrew T 1 Chang-Claude, Jenny 1 Chanock, Stephen J 1 Chen, Zhishan 1 Conti, David V 1 Corley, Douglas A 1
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Pracoviště
Biostatistics Division Kaiser Permane... 1 Broad Institute of Harvard and MIT Ca... 1 CIBER Epidemiología y Salud Pública M... 1 Cancer Epidemiology Division Cancer C... 1 Cancer Epidemiology Program H Lee Mof... 1 Center for Cancer Research Medical Un... 1 Center for Gastrointestinal Biology a... 1 Center for Public Health Genomics Uni... 1 Centre for Epidemiology and Biostatis... 1 Channing Division of Network Medicine... 1 Clinical and Translational Epidemiolo... 1 Colon Cancer Genetics Group Medical R... 1 Colorado Center for Personalized Medi... 1 Colorectal Cancer Group ONCOBELL Prog... 1 Colorectal Oncogenomics Group Departm... 1 Danish Institute for Advanced Study E... 1 Department of Bioinformatics and Medi... 1 Department of Biostatistics School of... 1 Department of Biostatistics Universit... 1 Department of Cancer Biomedical Scien... 1
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- Nejvíce citované
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Autor
Ahn, Yoon-Ok 1 Arndt, Volker 1 Berndt, Sonja I 1 Bishop, D Timothy 1 Brenner, Hermann 1 Brezina, Stefanie 1 Buchanan, Daniel D 1 Bujanda, Luis 1 Burnett-Hartman, Andrea 1 Cai, Qiuyin 1 Campbell, Peter T 1 Carreras-Torres, Robert 1 Casey, Graham 1 Castellví-Bel, Sergi 1 Chan, Andrew T 1 Chang-Claude, Jenny 1 Chanock, Stephen J 1 Chen, Zhishan 1 Conti, David V 1 Corley, Douglas A 1
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Pracoviště
Biostatistics Division Kaiser Permane... 1 Broad Institute of Harvard and MIT Ca... 1 CIBER Epidemiología y Salud Pública M... 1 Cancer Epidemiology Division Cancer C... 1 Cancer Epidemiology Program H Lee Mof... 1 Center for Cancer Research Medical Un... 1 Center for Gastrointestinal Biology a... 1 Center for Public Health Genomics Uni... 1 Centre for Epidemiology and Biostatis... 1 Channing Division of Network Medicine... 1 Clinical and Translational Epidemiolo... 1 Colon Cancer Genetics Group Medical R... 1 Colorado Center for Personalized Medi... 1 Colorectal Cancer Group ONCOBELL Prog... 1 Colorectal Oncogenomics Group Departm... 1 Danish Institute for Advanced Study E... 1 Department of Bioinformatics and Medi... 1 Department of Biostatistics School of... 1 Department of Biostatistics Universit... 1 Department of Cancer Biomedical Scien... 1
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Nejvíce citovaný článek - PubMed ID 10066353
- Thomas, Minta
- Su, Yu-Ru
- Rosenthal, Elisabeth A
- Sakoda, Lori C
- Schmit, Stephanie L
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Timofeeva, Maria N
Autor Timofeeva, Maria N ORCID Danish Institute for Advanced Study (DIAS), Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, U, Germany
- Chen, Zhishan
- Fernandez-Rozadilla, Ceres
- Law, Philip J
- Murphy, Neil
PubMed
37783704
PubMed Central
PMC10545678
DOI
10.1038/s41467-023-41819-0
PII: 10.1038/s41467-023-41819-0
Knihovny.cz E-zdroje
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
- MeSH
- celogenomová asociační studie MeSH
- etnicita * genetika MeSH
- genetická predispozice k nemoci MeSH
- jednonukleotidový polymorfismus MeSH
- kolorektální nádory * diagnóza genetika MeSH
- lidé MeSH
- multifaktoriální dědičnost MeSH
- rizikové faktory MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
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