Common variable immunodeficiency (CVID), the most frequent symptomatic immunoglobulin primary immunodeficiency, is associated with chronic T cell activation and reduced frequency of CD4(+) T cells. The underlying cause of immune activation in CVID is unknown. Microbial translocation indicated by elevated serum levels of lipopolysaccharide and soluble CD14 (sCD14) has been linked previously to systemic immune activation in human immunodeficiency virus/acquired immune deficiency syndrome (HIV-1/AIDS), alcoholic cirrhosis and other conditions. To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of immune cell populations and serum levels of sCD14, soluble CD25 (sCD25), lipopolysaccharide and markers of liver function in 35 patients with CVID, 53 patients with selective immunoglobulin (Ig)A deficiency (IgAD) and 63 control healthy subjects. In CVID subjects, the concentration of serum sCD14 was increased significantly and correlated with the level of sCD25, C-reactive protein and the extent of T cell activation. Importantly, no increase in serum lipopolysaccharide concentration was observed in patients with CVID or IgAD. Collectively, the data presented suggest that chronic T cell activation in CVID is associated with elevated levels of sCD14 and sCD25, but not with systemic endotoxaemia, and suggest involvement of lipopolysaccharide-independent mechanisms of induction of sCD14 production.

• MeSH
• aktivace lymfocytů MeSH
• antigeny CD14 krev   imunologie   MeSH
• B-lymfocyty imunologie   MeSH
• běžná variabilní imunodeficience krev   imunologie   MeSH
• bronchiektazie krev   MeSH
• C-reaktivní protein imunologie   metabolismus   MeSH
• deficience IgA krev   imunologie   MeSH
• dospělí MeSH
• endotoxemie krev   imunologie   MeSH
• granulom krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lipopolysacharidy krev   imunologie   MeSH
• mladiství MeSH
• mladý dospělý MeSH
• nemoci jater krev   MeSH
• receptor interleukinu-2 - alfa-podjednotka krev   imunologie   MeSH
• senioři MeSH
• splenomegalie krev   MeSH
• T-lymfocyty imunologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, N.I.H., Extramural MeSH
• Názvy látek
• antigeny CD14 MeSH
• C-reaktivní protein MeSH
• lipopolysacharidy MeSH
• receptor interleukinu-2 - alfa-podjednotka MeSH