Most cited article - PubMed ID 10424769
9-[2-(Phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases alpha, delta, epsilon, and epsilon*
Biochemical pharmacology.
1999 Aug 01 ;
58 (3) :
487-92.
Antimicrobial agents and chemotherapy.
2002 May ;
46 (5) :
1610-3.
Tenofovir diphosphate (PMPApp) is a weak inhibitor of DNA polymerases (pol) alpha, delta, and epsilon*, with values for the Ki for PMPApp ((PMPApp)Ki) relative to the Km for dATP ((dATP)Km) of 10.2, 10.2, and 15.2, respectively. Its incorporation into DNA was about 1,000-fold less efficient than that of dATP, with (PMPApp)Km values 350-, 2,155-, and 187-fold higher than (dATP)Km values for pol alpha, delta, and epsilon*, respectively.
- MeSH
- Adenine analogs & derivatives metabolism pharmacology MeSH
- DNA-Directed DNA Polymerase metabolism MeSH
- DNA Polymerase I antagonists & inhibitors metabolism MeSH
- DNA Polymerase II antagonists & inhibitors metabolism MeSH
- DNA Polymerase III antagonists & inhibitors metabolism MeSH
- Reverse Transcriptase Inhibitors metabolism pharmacology MeSH
- Nucleic Acid Synthesis Inhibitors * MeSH
- Rats MeSH
- Anti-HIV Agents metabolism pharmacology MeSH
- Organophosphonates * MeSH
- Organophosphorus Compounds metabolism pharmacology MeSH
- Tenofovir MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenine MeSH
- DNA-Directed DNA Polymerase MeSH
- DNA Polymerase I MeSH
- DNA Polymerase II MeSH
- DNA Polymerase III MeSH
- Reverse Transcriptase Inhibitors MeSH
- Nucleic Acid Synthesis Inhibitors * MeSH
- Anti-HIV Agents MeSH
- Organophosphonates * MeSH
- Organophosphorus Compounds MeSH
- Tenofovir MeSH
