Epigenetic modifications, such as acetylation, phosphorylation, methylation, ubiquitination, and ADP ribosylation, of the highly conserved core histones, H2A, H2B, H3, and H4, influence the genetic potential of DNA. The enormous regulatory potential of histone modification is illustrated in the vast array of epigenetic markers found throughout the genome. More than the other types of histone modification, acetylation and methylation of specific lysine residues on N-terminal histone tails are fundamental for the formation of chromatin domains, such as euchromatin, and facultative and constitutive heterochromatin. In addition, the modification of histones can cause a region of chromatin to undergo nuclear compartmentalization and, as such, specific epigenetic markers are non-randomly distributed within interphase nuclei. In this review, we summarize the principles behind epigenetic compartmentalization and the functional consequences of chromatin arrangement within interphase nuclei.

• MeSH
• acetylace MeSH
• buněčné jádro metabolismus   ultrastruktura   MeSH
• chromatin ultrastruktura   MeSH
• chromozomální proteiny, nehistonové fyziologie   MeSH
• epigeneze genetická MeSH
• exprese genu MeSH
• histony genetika   metabolismus   MeSH
• homolog proteinu s chromoboxem 5 MeSH
• inhibitory histondeacetylas MeSH
• interfáze MeSH
• lidé MeSH
• lidské chromozomy X metabolismus   MeSH
• metylace MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• chromatin MeSH
• chromozomální proteiny, nehistonové MeSH
• histony MeSH
• homolog proteinu s chromoboxem 5 MeSH
• inhibitory histondeacetylas MeSH