The active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats divided into 4 groups: Group I served as control group, and Group II received weekly i.p. injection of 2 mL CCl4/kg bwt for 12 weeks. Group III were supplemented with Physalis juice via the drinking water. The animals of Group IV received Physalis juice as Group III and also were intraperitoneally injected weekly with 2 mL CCl4/kg bwt for 12 weeks. Hepatoprotective effect was evaluated by improvement in liver enzymes serum levels, reduction in collagen areas, downregulation in expression of the fibrotic marker MMP-9, reduction in the peroxidative marker malonaldehyde and the inflammatory marker nitric oxide, and restoration of the activity of antioxidant enzymatic and nonenzymatic systems, namely, glutathione content, superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase activities. The results show that the potential hepatoprotective effects of Physalis peruviana may be due to physalis acts by promotion of processes that restore hepatolobular architecture and through the inhibition of oxidative stress pathway.

• MeSH
• chlorid uhličitý toxicita   MeSH
• down regulace účinky léků   MeSH
• jaterní testy MeSH
• játra účinky léků   metabolismus   patologie   MeSH
• krysa rodu Rattus MeSH
• lékové postižení jater farmakoterapie   etiologie   patologie   MeSH
• malondialdehyd krev   MeSH
• matrixová metaloproteinasa 9 metabolismus   MeSH
• ochranné látky farmakologie   terapeutické užití   MeSH
• oxid dusnatý metabolismus   MeSH
• oxidační stres účinky léků   MeSH
• oxidoreduktasy krev   metabolismus   MeSH
• Physalis chemie   metabolismus   MeSH
• potkani Wistar MeSH
• rostlinné extrakty chemie   farmakologie   terapeutické užití   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• chlorid uhličitý MeSH
• malondialdehyd MeSH
• matrixová metaloproteinasa 9 MeSH
• ochranné látky MeSH
• oxid dusnatý MeSH
• oxidoreduktasy MeSH
• rostlinné extrakty MeSH