Colorectal cancer (CRC) is a heterogeneous disease that includes both hereditary and sporadic types of tumors. Tumor initiation and growth is driven by mutational or epigenetic changes that alter the function or expression of multiple genes. The genes predominantly encode components of various intracellular signaling cascades. In this review, we present mouse intestinal cancer models that include alterations in the Wnt, Hippo, p53, epidermal growth factor (EGF), and transforming growth factor β (TGFβ) pathways; models of impaired DNA mismatch repair and chemically induced tumorigenesis are included. Based on their molecular biology characteristics and mutational and epigenetic status, human colorectal carcinomas were divided into four so-called consensus molecular subtype (CMS) groups. It was shown subsequently that the CMS classification system could be applied to various cell lines derived from intestinal tumors and tumor-derived organoids. Although the CMS system facilitates characterization of human CRC, individual mouse models were not assigned to some of the CMS groups. Thus, we also indicate the possible assignment of described animal models to the CMS group. This might be helpful for selection of a suitable mouse strain to study a particular type of CRC.

• Klíčová slova
• carcinoma, consensus molecular subtypes, intestine, oncogenes, signaling cascades, tumor suppressors, tumorigenesis,
• MeSH
• epidermální růstový faktor genetika   MeSH
• geny p53 genetika   MeSH
• karcinogeneze genetika   MeSH
• kolorektální nádory klasifikace   metabolismus   patofyziologie   MeSH
• lidé MeSH
• modely nemocí na zvířatech MeSH
• myši MeSH
• nádorová transformace buněk genetika   MeSH
• nádory tračníku genetika   MeSH
• oprava chybného párování bází DNA genetika   MeSH
• protein-serin-threoninkinasy genetika   MeSH
• regulace genové exprese u nádorů genetika   MeSH
• signální dráha Hippo MeSH
• signální dráha Wnt genetika   MeSH
• transformující růstový faktor beta genetika   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• epidermální růstový faktor MeSH
• protein-serin-threoninkinasy MeSH
• transformující růstový faktor beta MeSH