Invasive disease caused by the encapsulated bacteria Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae remains an important cause of morbidity and mortality worldwide, despite the introduction of successful conjugate polysaccharide vaccines that target disease-associated strains. In addition, resistance, or more accurately reduced susceptibility, to therapeutic antibiotics is spreading in populations of these organisms. There is therefore a continuing requirement for the surveillance of vaccine and non-vaccine antigens and antibiotic susceptibilities among isolates from invasive disease, which is only partially met by conventional methods. This need can be met with molecular and especially nucleotide sequence-based typing methods, which are fully developed in the case of N. meningitidis and which could be more widely deployed in clinical laboratories for S. pneumoniae and H. influenzae.

• MeSH
• epidemický výskyt choroby MeSH
• Haemophilus influenzae klasifikace   genetika   izolace a purifikace   MeSH
• hemofilové infekce epidemiologie   mikrobiologie   MeSH
• lidé MeSH
• meningokokové infekce epidemiologie   mikrobiologie   MeSH
• mikrobiální testy citlivosti MeSH
• molekulární epidemiologie metody   MeSH
• molekulární typizace metody   MeSH
• Neisseria meningitidis klasifikace   genetika   izolace a purifikace   MeSH
• pneumokokové infekce epidemiologie   mikrobiologie   MeSH
• Streptococcus pneumoniae klasifikace   genetika   izolace a purifikace   MeSH
• surveillance populace metody   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH