Five new 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-propoxybenzoates were designed and synthesized as potential dual antihypertensive agents. The compounds were prepared as free bases and subsequently transformed to hydrochloride salts. The position of protonation of nitrogen atoms in the piperazine ring of hydrochloride salts was determined by means of (13)C-CP/MAS and (15)N-CP/MAS NMR and IR spectroscopy. Using these solid-state analytical techniques, it was found that both nitrogen atoms were protonated when excess hydrogen chloride was used for preparation of salts. On the other hand, when the equimolar amount of hydrogen chloride was used, piperazine nitrogen substituted by aryl was protonated.

• Klíčová slova
• CP/MAS NMR spectroscopy, IR spectroscopy, arylcarbonyloxyaminopropanols, phenylpiperazines, principle components analysis, synthesis,
• MeSH
• antihypertenziva chemická syntéza   chemie   MeSH
• benzoáty chemická syntéza   chemie   MeSH
• magnetická rezonanční spektroskopie MeSH
• molekulární konformace MeSH
• molekulární modely MeSH
• piperazin MeSH
• piperaziny chemie   MeSH
• soli chemie   MeSH
• spektroskopie infračervená s Fourierovou transformací MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antihypertenziva MeSH
• benzoáty MeSH
• piperazin MeSH
• piperaziny MeSH
• soli MeSH