Coronary artery disease (CAD) has significant social and economic implications. It is necessary to create tools to identify the most cost-effectiveness treatments, which can assist clinicians in their therapeutic decisions so that the maximum possible benefit is reached with the lowest possible cost. Effectiveness must be measured by final treatment goals in which the most effective interventions are those with the lowest costs. This study is aimed to systematically review and compare the studies conducted on the cost-effectiveness of the three coronary artery disease treatment strategies (medical treatment, percutaneous coronary intervention, and coronary artery bypass graft). In this systematic review, the databases NHS Economic Evaluation Database, Embase, MEDLINE, Science Direct, and Scopus were searched for studies on the cost-effectiveness of coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) compared to medical therapy (MT) in patients with coronary artery disease between 1 January 2004 to 30 September 2018. The quality appraisal of the included studies was examined using the Consolidated Health Economics Evaluation Reporting Standards (CHEERS) statement. Out of 186 unique retrievals, 8 studies were included. The results showed that the all studies clearly stated the time horizon of the study and included direct medical costs in their analysis. In addition, in most of the studies, quality-adjusted life years (QALY) were the main outcome used for measuring the effectiveness. The studies reported various ranges of the incremental cost-effectiveness ratio (ICER); accordingly, the highest ratio was observed in the USA ($212,800) for PCI v MT and the lowest ratio was observed in Brazil ($4403) for CABG v MT. Although the results of the studies were different in terms of a number of aspects, such as the viewpoint of the study, the study horizons, and the costs of expenditure items, they reached similar results. Based on the result of the present study, it seems that each three treatment strategies for CAD yielded improvements in QALY.

• Klíčová slova
• Coronary artery bypass graft, Coronary artery disease, Cost-effectiveness, Economic evaluation, Medical therapy, Percutaneous coronary intervention,
• MeSH
• analýza nákladů a výnosů metody   MeSH
• koronární angioplastika ekonomika   metody   MeSH
• koronární bypass ekonomika   metody   MeSH
• kvalitativně upravené roky života MeSH
• lidé MeSH
• nemoci koronárních tepen farmakoterapie   psychologie   chirurgie   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• systematický přehled MeSH
• Geografické názvy
• Anglie epidemiologie   MeSH
• Argentina epidemiologie   MeSH
• Brazílie epidemiologie   MeSH
• Česká republika epidemiologie   MeSH
• Mexiko epidemiologie   MeSH
• Nizozemsko epidemiologie   MeSH
• Rakousko epidemiologie   MeSH
• Spojené státy americké epidemiologie   MeSH
• Švýcarsko epidemiologie   MeSH
• Wales epidemiologie   MeSH