Among external stimuli used to trigger release of a drug from a polymeric carrier, ultrasound has gained increasing attention due to its non-invasive nature, safety and low cost. Despite this attention, there is only limited knowledge about how materials available for the preparation of drug carriers respond to ultrasound. This study investigates the effect of ultrasound on the release of a hydrophobic drug, dexamethasone, from poly(2-oxazoline)-based micelles. Spontaneous and ultrasound-mediated release of dexamethasone from five types of micelles made of poly(2-oxazoline) block copolymers, composed of hydrophilic poly(2-methyl-2-oxazoline) and hydrophobic poly(2-n-propyl-2-oxazoline) or poly(2-butyl-2-oxazoline-co-2-(3-butenyl)-2-oxazoline), was studied. The release profiles were fitted by zero-order and Ritger-Peppas models. The ultrasound increased the amount of released dexamethasone by 6% to 105% depending on the type of copolymer, the amount of loaded dexamethasone, and the stimulation time point. This study investigates for the first time the interaction between different poly(2-oxazoline)-based micelle formulations and ultrasound waves, quantifying the efficacy of such stimulation in modulating dexamethasone release from these nanocarriers.

• MeSH
• dexamethason farmakokinetika   MeSH
• dynamický rozptyl světla MeSH
• hydrofobní a hydrofilní interakce MeSH
• lékové transportní systémy metody   MeSH
• micely MeSH
• nosiče léků chemie   farmakokinetika   MeSH
• oxazoly chemie   MeSH
• polymery chemie   MeSH
• transmisní elektronová mikroskopie MeSH
• ultrazvuk metody   MeSH
• vysokoúčinná kapalinová chromatografie MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• dexamethason MeSH
• micely MeSH
• nosiče léků MeSH
• oxazoly MeSH
• poly(2-oxazoline) MeSH Prohlížeč
• polymery MeSH