In European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the past 10,000 years1. Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions2,3. Here we provide detailed distributions of milk exploitation across Europe over the past 9,000 years using around 7,000 pottery fat residues from more than 550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Notably, LP selection varying with levels of prehistoric milk exploitation is no better at explaining LP allele frequency trajectories than uniform selection since the Neolithic period. In the UK Biobank4,5 cohort of 500,000 contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests that other reasons for the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available but, under conditions of famine and/or increased pathogen exposure, this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitation-proxies for these drivers-provide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution.

• MeSH
• archeologie * MeSH
• banky biologického materiálu MeSH
• dějiny starověku MeSH
• divoká zvířata MeSH
• frekvence genu MeSH
• genotyp MeSH
• hladomor statistika a číselné údaje   MeSH
• keramika dějiny   MeSH
• kohortové studie MeSH
• laktasa * genetika   MeSH
• lidé MeSH
• mlékárenství * dějiny   MeSH
• mléko * metabolismus   MeSH
• nemoc * MeSH
• populační genetika * MeSH
• selekce (genetika) * MeSH
• zvířata MeSH
• Check Tag
• dějiny starověku MeSH
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• historické články MeSH
• Geografické názvy
• Evropa epidemiologie   etnologie   MeSH
• Spojené království MeSH
• Názvy látek
• laktasa * MeSH