The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.

• Klíčová slova
• LAA specific T cells, allogenic natural killer cells, animal models, donor lymphocyte infusion, graft-versus-leukemia effect, invariant natural killer T cells (i)NKT, leukaemia associated antigens (LAA), leukaemia derived dendritic cells, leukaemia specific antigens,
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH