A small library of boron-cluster- and metallacarborane-cluster-based ligands was designed, prepared, and tested for isoform-selective activation or inhibition of the three nitric oxide synthase isoforms. On the basis of the concept of creating a hydrophobic analogue of a natural substrate, a stable and nontoxic basic boron cluster system, previously used for boron neutron capture therapy, was modified by the addition of positively charged moieties to its periphery, providing hydrophobic and nonclassical hydrogen bonding interactions with the protein. Several of these compounds show efficacy for inhibition of NO synthesis with differential effects on the various nitric oxide synthase isoforms.

• MeSH
• chemické modely MeSH
• kobalt chemie   MeSH
• lidé MeSH
• molekulární struktura MeSH
• organokovové sloučeniny chemická syntéza   farmakologie   MeSH
• protein - isoformy MeSH
• sloučeniny boru chemická syntéza   farmakologie   MeSH
• synthasa oxidu dusnatého antagonisté a inhibitory   metabolismus   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, N.I.H., Extramural MeSH
• Názvy látek
• kobalt MeSH
• organokovové sloučeniny MeSH
• protein - isoformy MeSH
• sloučeniny boru MeSH
• synthasa oxidu dusnatého MeSH