1,2-Bis-[2-(5-H/Me/Cl/NO2)-1H-benzimidazolyl]-1,2-ethanediols (L1-L4), 1,4-bis-[2-(5-H/Me/Cl)-1H-benzimidazolyl]-1,2,3,4-butanetetraols (L5-L7) and their complexes with ZnCl2, CdCl2 and HgCl2 were synthesized and antibacterial activity of the compounds was tested toward Staphylococcus aureus, S. epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Proteus mirabilis and antifungal activity against Candida albicans. HgII complexes have a considerably higher antimicrobial activity against all microorganisms. Some HgII complexes show higher antifungal activity than clotrimazole toward C. albicans. Zn2(L3)Cl4, Zn2(L4)Cl4, and Cd(L3)Cl2 were moderately effective against S. aureus and S. epidermidis; Cd(L4)Cl2 exhibited a weak activity only against S. epidermidis.

• MeSH
• antiinfekční látky chemická syntéza   chemie   farmakologie   MeSH
• Bacteria účinky léků   MeSH
• benzimidazoly chemická syntéza   chemie   farmakologie   MeSH
• butany chemie   farmakologie   MeSH
• Candida albicans účinky léků   MeSH
• ethylenglykoly chemie   farmakologie   MeSH
• kadmium chemie   farmakologie   MeSH
• ligandy MeSH
• mikrobiální testy citlivosti MeSH
• rtuť chemie   farmakologie   MeSH
• spektrofotometrie infračervená MeSH
• těžké kovy chemie   farmakologie   MeSH
• zinek chemie   farmakologie   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antiinfekční látky MeSH
• benzimidazoly MeSH
• butany MeSH
• ethylenglykoly MeSH
• kadmium MeSH
• ligandy MeSH
• rtuť MeSH
• těžké kovy MeSH
• zinek MeSH

Antifungal activity of new copper(II) complexes of 2-methylthionicotinate (2-MeSNic) of the composition Cu(2-MeSNic)2(MeNia)(2).4H2O (where MeNia is N-methylnicotinamide), and Cu(2-MeSNic)2(Nia)(2).2H2O (where Nia is nicotinamide) and Cu(2-MeSNic)2L2 (where L is isonicotinamide, iNia, or ethyl nicotinate, EtNic) were tested on various strains of filamentous fungi by the macrodilution method. Most sensitive against copper(II) adducts with bioactive ligands were Rhizopus oryzae and Microsporum gypseum (IC50 1.5-2.3 mmol/L). The adducts with Nia, MeNia and EtNic at 5 mmol/L induced morphological changes in growing hyphae of Botrytis cinerea, mainly their intensive branching attached to release of cytoplasm with partial growth inhibition. Inhibition of sporulation (> 90%) of Alternaria alternata by Cu(2-MeSNic)2.H2O was observed as a change in the color of the colonies. The highest resistance was marked by B. cinerea and Fusarium moniliforme (average IC50 values 4.25 and 3.13 mmol/L, respectively). The presence of all bioactive ligands in copper(II) complexes caused an increase in the inhibition effect against model fungi (except significant inhibition activity of EtNic on R. oryzae).

• MeSH
• Alternaria účinky léků   MeSH
• antifungální látky chemie   farmakologie   MeSH
• Fusarium účinky léků   MeSH
• měď chemie   farmakologie   MeSH
• mikrobiální testy citlivosti MeSH
• organokovové sloučeniny farmakologie   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antifungální látky MeSH
• měď MeSH
• organokovové sloučeniny MeSH