Antimicrobial activity of ZnII, CdII, and HgII complexes of 1,2-bis-[2-(5-R)-1H-benzimidazolyl]-1,2-ethanediols and 1,4-bis-[2-(5-R)-1H-benzimidazolyl]-1,2,3,4-butanetetraols
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16681142
DOI
10.1007/bf02931432
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents chemical synthesis chemistry pharmacology MeSH
- Bacteria drug effects MeSH
- Benzimidazoles chemical synthesis chemistry pharmacology MeSH
- Butanes chemistry pharmacology MeSH
- Candida albicans drug effects MeSH
- Ethylene Glycols chemistry pharmacology MeSH
- Cadmium chemistry pharmacology MeSH
- Ligands MeSH
- Microbial Sensitivity Tests MeSH
- Mercury chemistry pharmacology MeSH
- Spectrophotometry, Infrared MeSH
- Metals, Heavy chemistry pharmacology MeSH
- Zinc chemistry pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Infective Agents MeSH
- Benzimidazoles MeSH
- Butanes MeSH
- Ethylene Glycols MeSH
- Cadmium MeSH
- Ligands MeSH
- Mercury MeSH
- Metals, Heavy MeSH
- Zinc MeSH
1,2-Bis-[2-(5-H/Me/Cl/NO2)-1H-benzimidazolyl]-1,2-ethanediols (L1-L4), 1,4-bis-[2-(5-H/Me/Cl)-1H-benzimidazolyl]-1,2,3,4-butanetetraols (L5-L7) and their complexes with ZnCl2, CdCl2 and HgCl2 were synthesized and antibacterial activity of the compounds was tested toward Staphylococcus aureus, S. epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Proteus mirabilis and antifungal activity against Candida albicans. HgII complexes have a considerably higher antimicrobial activity against all microorganisms. Some HgII complexes show higher antifungal activity than clotrimazole toward C. albicans. Zn2(L3)Cl4, Zn2(L4)Cl4, and Cd(L3)Cl2 were moderately effective against S. aureus and S. epidermidis; Cd(L4)Cl2 exhibited a weak activity only against S. epidermidis.
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