Antimicrobial activity of FeIII, CuII, AgI, ZnII and HgII complexes of 2-(2-hydroxy-5-bromo/nitro-phenyl)-1H- and 2-(2-hydroxyphenyl)-5-methyl/chloro/nitro-1H-benzimidazoles
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12503391
DOI
10.1007/bf02818785
Knihovny.cz E-resources
- MeSH
- Bacteria drug effects MeSH
- Benzimidazoles chemical synthesis chemistry pharmacology MeSH
- Candida albicans drug effects MeSH
- Nitrates chemistry MeSH
- Ligands MeSH
- Microbial Sensitivity Tests MeSH
- Spectrophotometry, Infrared MeSH
- Metals, Heavy chemistry MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Benzimidazoles MeSH
- Nitrates MeSH
- Ligands MeSH
- Metals, Heavy MeSH
Antimicrobial activity of 2-(2-hydroxyphenyl)-5-R5-1H-benzimidazoles, 2-(2-hydroxy-5-R5'-phenyl)-1H-benzimidazoles and their FeIII, CuII, AgI, ZnII and HgII nitrate complexes was tested toward Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, and Proteus mirabilis. Antifungal activity was tested against Candida albicans. Benzimidazole benzene ring substituents increase the antimicrobial activity, phenol ring substituents decrease it. The ligands show an antibacterial effect against only S. aureus whereas AgI and HgII complexes of the ligands have a higher activity with respect to the other complexes to all the bacteria. On the other hand, FeIII complexes show a considerable activity against S. aureus and S. epidermidis.
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