Antimicrobial activity of 1,2-bis-[2-(5-R)-1H-benzimidazolyl]- 1,2-ethanediols, 1,4-bis-[2-(5-R)-1H-benzimidazolyl]- 1,2,3,4-butanetetraols and their FeIII, CuII, and AgI complexes
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16681141
DOI
10.1007/bf02931431
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents chemical synthesis chemistry pharmacology MeSH
- Bacteria drug effects MeSH
- Benzimidazoles chemical synthesis chemistry pharmacology MeSH
- Butanes chemistry pharmacology MeSH
- Candida albicans drug effects MeSH
- Ethylene Glycols chemistry pharmacology MeSH
- Ligands MeSH
- Magnetics MeSH
- Microbial Sensitivity Tests methods MeSH
- Spectrophotometry, Infrared MeSH
- Metals, Heavy chemistry pharmacology MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Infective Agents MeSH
- Benzimidazoles MeSH
- Butanes MeSH
- Ethylene Glycols MeSH
- Ligands MeSH
- Metals, Heavy MeSH
1,2-Bis-[2-(5-H/Me/Cl/NO2)-1H-benzimidazolyl]-1,2-ethanediols (L1-L4), 1,4-Bis-[2-(5-H/Me/Cl)-1H-benzimidazolyl]-1,2,3,4-butanetetraols (L5-L7) and their complexes with FeCl3, CuCl2, and AgNO3 were synthesized; antibacterial activity of the compounds was determined toward Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Proteus mirabilis, and antifungal activity against Candida albicans. The AgI complexes have considerable activity toward the microorganisms. Some AgI complexes show higher activity toward S. epidermidis than AgNO3 and cefuroxime. Cu(L3)Cl2 and Fe(L3)Cl3 show an antifungal effect on C. albicans but L3 itself has no activity.
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