Biological properties of new copper(II) complexes of 2-methylthionicotinate (2-MeSNic) of composition Cu(2-MeSNic)2(MeNia)(2).4H2O (where MeNia is N-methyl-nicotinamide), Cu(2-MeSNic)2(Nia)(2).2H2O (where Nia is nicotinamide) and Cu(2-MeSNic)2L2 (where L is isonicotinamide (iNia) or ethyl nicotinate (EtNic)) are reported. Gram(-)-bacteria (Escherichia coli) are more resistant against Cu(II) complexes than Gram(+)-bacteria (Staphylococcus aureus)--significant antistaphylococcal activity was found with Cu(2-MeSNic)2(MeNia)(2).4H2O (IC50 1.3 mmol/L). Candida parapsilosis was most inhibited by Cu(2-MeSNic)2.H2O and Cu(2-MeSNic)2(MeNia)(2).4H2O (IC50 1.4 mmol/L and 1.5 mmol/L, respectively). Biosynthesis of nucleic acids influenced by Cu(2-MeSNic)2(Nia)(2).2H2O indicated by incorporation of 14C-adenine (IC50(Ade) 0.31 mmol/L) is more sensitive than biosynthesis of proteins indicated by incorporation of 14C-leucine (IC50(Leu) 9.94 mmol/L). Cu(II) complexes with expressed antimicrobial activity showed no mutagenic activity.

Department of Biochemistry and Microbiology Faculty of Chemical Technology Slovak University of Technology 812 37 Bratislava Slovakia

Zobrazit více v PubMed

Neoplasma. 1998;45(4):254-60 PubMed

Folia Microbiol (Praha). 2000;45(6):573-5 PubMed

Ceska Slov Farm. 1994 Oct;43(5):237-9 PubMed

Ceska Slov Farm. 1998 Mar;47(2):91-4 PubMed

Arzneimittelforschung. 1995 Sep;45(9):1021-3 PubMed

Folia Microbiol (Praha). 1997;42(4):324-6 PubMed

Folia Microbiol (Praha). 1996;41(6):473-6 PubMed

Mutat Res. 1983 May;113(3-4):173-215 PubMed

Anticancer Drugs. 1993 Jun;4(3):355-63 PubMed

Antimicrobial activity of ZnII, CdII, and HgII complexes of 1,2-bis-[2-(5-R)-1H-benzimidazolyl]-1,2-ethanediols and 1,4-bis-[2-(5-R)-1H-benzimidazolyl]-1,2,3,4-butanetetraols

Copper complexes with bioactive ligands. Part II--Antifungal activity