Biological properties of new copper(II) complexes of 2-methylthionicotinate (2-MeSNic) of composition Cu(2-MeSNic)2(MeNia)(2).4H2O (where MeNia is N-methyl-nicotinamide), Cu(2-MeSNic)2(Nia)(2).2H2O (where Nia is nicotinamide) and Cu(2-MeSNic)2L2 (where L is isonicotinamide (iNia) or ethyl nicotinate (EtNic)) are reported. Gram(-)-bacteria (Escherichia coli) are more resistant against Cu(II) complexes than Gram(+)-bacteria (Staphylococcus aureus)--significant antistaphylococcal activity was found with Cu(2-MeSNic)2(MeNia)(2).4H2O (IC50 1.3 mmol/L). Candida parapsilosis was most inhibited by Cu(2-MeSNic)2.H2O and Cu(2-MeSNic)2(MeNia)(2).4H2O (IC50 1.4 mmol/L and 1.5 mmol/L, respectively). Biosynthesis of nucleic acids influenced by Cu(2-MeSNic)2(Nia)(2).2H2O indicated by incorporation of 14C-adenine (IC50(Ade) 0.31 mmol/L) is more sensitive than biosynthesis of proteins indicated by incorporation of 14C-leucine (IC50(Leu) 9.94 mmol/L). Cu(II) complexes with expressed antimicrobial activity showed no mutagenic activity.

Department of Biochemistry and Microbiology Faculty of Chemical Technology Slovak University of Technology 812 37 Bratislava Slovakia

See more in PubMed

Neoplasma. 1998;45(4):254-60 PubMed

Folia Microbiol (Praha). 2000;45(6):573-5 PubMed

Ceska Slov Farm. 1994 Oct;43(5):237-9 PubMed

Ceska Slov Farm. 1998 Mar;47(2):91-4 PubMed

Arzneimittelforschung. 1995 Sep;45(9):1021-3 PubMed

Folia Microbiol (Praha). 1997;42(4):324-6 PubMed

Folia Microbiol (Praha). 1996;41(6):473-6 PubMed

Mutat Res. 1983 May;113(3-4):173-215 PubMed

Anticancer Drugs. 1993 Jun;4(3):355-63 PubMed

Antimicrobial activity of ZnII, CdII, and HgII complexes of 1,2-bis-[2-(5-R)-1H-benzimidazolyl]-1,2-ethanediols and 1,4-bis-[2-(5-R)-1H-benzimidazolyl]-1,2,3,4-butanetetraols

Copper complexes with bioactive ligands. Part II--Antifungal activity