Antimicrobial effects of the macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde complex
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
9449779
DOI
10.1007/bf02816943
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Antifungal Agents pharmacology MeSH
- Bacillus subtilis drug effects MeSH
- Escherichia coli drug effects MeSH
- Microbial Sensitivity Tests MeSH
- Organometallic Compounds pharmacology MeSH
- Pseudomonas aeruginosa drug effects MeSH
- Staphylococcus aureus drug effects MeSH
- Superoxide Dismutase metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Antifungal Agents MeSH
- copper tetrabenzo(b,f,j,n)-1,5,9,13-tetraazacyclohexadecine MeSH Browser
- Organometallic Compounds MeSH
- Superoxide Dismutase MeSH
The Cu(II)-tetraaza macrocyclic complex exhibited antimicrobial effects on bacteria, yeasts and filamentous fungi. The highest antibacterial activity was found with B. subtilis and S. aureus, the respective IC50 values being 18 and 80 micrograms/L and the MIC values 50 and 1000 micrograms/L. A concentration of 1 mg/L exerted a bacteriocide effect on S. aureus. The MIC value for B. subtilis was 250 times lower and for P. aeruginosa 10 times lower than the corresponding values for ampicillin. The Cu-complex was inactive against all tested yeasts. The strongest antifungal effect was manifested for R. nigricans, with an IC50 value under 0.1 mg/L, whereas in A. alternata the IC50 was 13.5 mg/L.
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