Antibacterial effect of some 2,6-disubstituted 4-anilinoquinazolines
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10189231
DOI
10.1007/bf02816389
Knihovny.cz E-resources
- MeSH
- Aniline Compounds chemistry pharmacology MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Drug Resistance, Microbial MeSH
- Bacillus subtilis drug effects MeSH
- Quinazolines chemistry pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Staphylococcus aureus drug effects MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Aniline Compounds MeSH
- Anti-Bacterial Agents MeSH
- Quinazolines MeSH
Two synthetic 2,6-disubstituted 4-anilinoquinazolines exerted a significant effect on the G+ bacteria Bacillus subtilis and staphylococcus aureus. None of 12 tested derivatives influenced Escherichia coli, Proteus mirabilis and Pseudomonas aeruginosa. Derivatives having the aromatic ring non-substituted or substituted by bromine, the pyrimidine ring by phenyl, morpholine or piperidine and the aniline skeleton non-substituted or substituted by methyl or amino group exerted a considerable antibacterial activity.
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