Antimicrobial activity of some substituted triazoloquinazolines
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16110909
DOI
10.1007/bf02931453
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Antifungal Agents pharmacology MeSH
- Bacillus subtilis drug effects growth & development MeSH
- Quinazolines chemistry pharmacology MeSH
- Fungi drug effects growth & development MeSH
- Microbial Sensitivity Tests MeSH
- Staphylococcus aureus drug effects growth & development MeSH
- Triazoles chemistry pharmacology MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Antifungal Agents MeSH
- Quinazolines MeSH
- Triazoles MeSH
Fifteen substituted 1,2,4-triazolo[4,3-c]quinazolines were tested for antibacterial and antifungal effects. The most effective derivatives had the triazoloquinazoline skeleton substituted with the pharmacologically active chromophores--morpholine, chlorine and nitro group. The broadest antimicrobial activity was found with 5-morpholin-4-yl-3-(5-nitrothien-2-yl)[1,2,4]triazolo[4,3-c]quinazoline in concentration of 10 mg/L for B. subtilis, 50 mg/L for S. aureus and 100 mg/L for C. tropicalis. The highest tested concentration of derivative caused 83% growth inhibition of R. nigricans.
See more in PubMed
Folia Microbiol (Praha). 1995;40(6):611-4 PubMed
Boll Chim Farm. 2002 Jan-Feb;141(1):84-91 PubMed
Folia Microbiol (Praha). 1997;42(4):324-6 PubMed
J Med Chem. 1986 Nov;29(11):2403-9 PubMed
J Med Chem. 1995 Sep 1;38(18):3608-16 PubMed
Folia Microbiol (Praha). 1996;41(6):473-6 PubMed
Anticancer Drugs. 1997 Jan;8(1):3-16 PubMed
Farmaco. 1995 Dec;50(12):857-66 PubMed
Farmaco. 1990 Apr;45(4):431-8 PubMed
Boll Chim Farm. 2002 Sep-Oct;141(5):372-8 PubMed
J Med Chem. 1996 Mar 29;39(7):1433-7 PubMed
Arch Pharm (Weinheim). 2003 Dec;336(12):560-6 PubMed
In vitro antifungal activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones
