Polymorphic markers identified in the horse genes encoding the interleukin 12 p40 subunit, interferon gamma, tumor necrosis factor receptor 1, and inducible nitric oxide synthase were identified and tested, along with additional markers, for associations with two important horse infections: Rhodococcus equi and Lawsonia intracellularis. Eight immune response-related and 14 microsatellite loci covering 12 out of 31 equine autosomes were used for the association analysis. Markers located on horse Chromosomes Eca10 and 15 were significantly associated with the presence of high numbers of R. equi in transtracheal aspirates. Significant associations of markers located on Eca9, 15, and 21 with fecal shedding of Lawsonia intracellularis were found. Marginal associations with tumor necrosis factor alpha, interferon gamma, and other genes suggested that variations in immune response-related genes could underlie the phenotypic variation observed.

• MeSH
• Genetic Predisposition to Disease * MeSH
• Genes, MHC Class II * genetics   immunology   MeSH
• Interferon-gamma genetics   immunology   MeSH
• Interleukin-12 genetics   immunology   MeSH
• Horses genetics   immunology   microbiology   MeSH
• Lawsonia Bacteria metabolism   MeSH
• Polymorphism, Genetic * MeSH
• Rhodococcus equi metabolism   MeSH
• Chromosomes, Mammalian genetics   MeSH
• Nitric Oxide Synthase Type II MeSH
• Nitric Oxide Synthase genetics   immunology   MeSH
• Tumor Necrosis Factor-alpha genetics   immunology   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Interferon-gamma MeSH
• Interleukin-12 MeSH
• Nitric Oxide Synthase Type II MeSH
• Nitric Oxide Synthase MeSH
• Tumor Necrosis Factor-alpha MeSH