Both prenatal and postnatal excessive consumption of dietary sucrose or fructose was shown to be detrimental to health and contributing to pathogenesis of metabolic syndrome. Our knowledge of genetic determinants of individual sensitivity to sucrose-driven metabolic effects is limited. In this study, we have tested the hypothesis that a variation of metabolic syndrome-related gene, Zbtb16 (Zinc Finger and BTB Domain Containing 16 will affect the reaction to high-sucrose diet (HSD) content in "matched" nutritional exposition settings, i.e. maternal HSD with re-exposition to HSD in adulthood vs. standard diet. We compared metabolic profiles of adult males of spontaneously hypertensive rats (SHR) and a single-gene, minimal congenic strain SHR-Zbtb16 fed either standard diet or exposed to HSD prenatally throughout gestation and nursing and again at the age of 6 months for the period of 14 days. HSD exposition led to increased adiposity in both strains and decrease of glucose tolerance and cholesterol (Ch) concentrations in majority of low-density lipoprotein (LDL) particle classes and in very large and large high-density lipoprotein (HDL) in SHR-Zbtb16 male offspring. There was a similar pattern of HSD-induced increase of triacylglycerols in chylomicrons and very low-density lipoprotein (VLDL) of both strains, though the increase of (triacylglycerol) TAG content was clearly more pronounced in SHR. We observed significant STRAIN*DIET interactions for the smallest LDL particles as their TAG content decreased in SHR-Zbtb16 and did not change in SHR in response to HSD. In summary, we provide evidence of nutrigenetic interaction between Zbtb16 and HSD in context of pathogenesis of metabolic syndrome.

• MeSH
• Cholesterol metabolism   MeSH
• Hypertension genetics   metabolism   MeSH
• Dietary Sucrose metabolism   MeSH
• Rats MeSH
• Metabolic Syndrome etiology   metabolism   pathology   MeSH
• Disease Models, Animal MeSH
• Nutrigenomics methods   MeSH
• Rats, Inbred SHR MeSH
• Promyelocytic Leukemia Zinc Finger Protein genetics   metabolism   MeSH
• Sweetening Agents metabolism   MeSH
• Pregnancy MeSH
• Triglycerides metabolism   MeSH
• Animals, Congenic MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Male MeSH
• Pregnancy MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Cholesterol MeSH
• Dietary Sucrose MeSH
• Promyelocytic Leukemia Zinc Finger Protein MeSH
• Sweetening Agents MeSH
• Triglycerides MeSH
• ZBTB16 protein, rat MeSH Browser