INTRODUCTION: Hypothyroidism (HT) has been found a predictor of cardiovascular diseases. We aimed to ascertain the prevalence of HT in patients with manifest coronary heart disease (CHD), and to establish its association with conventional risk factors. METHODS: 410 patients, 6-24 months after hospitalization for acute coronary syndrome, and/or revascularization, were included into the cross-sectional study. RESULTS: The prevalence of thyroid dysfunction was found in males and females as follows: overt HT, ie, thyroid stimulating hormone (TSH) > 3.65 mIU/L and free thyroxine (fT4) < 9 pmol/L and/or L-thyroxine substitution, in 2.6% and 8.4%, respectively; subclinical HT (TSH > 3.65, fT4 9-23 and no substitution) in 4.3% and 15.0%, respectively. Higher prevalence of HT was found in females with hypercholesterolemia, and in males and females with concomitant positive thyroid peroxidase antibodies. Hypothyroid subjects had higher total homocysteine in both genders and von Willebrand factor in males only. Hypothyroid females had higher total and LDL cholesterol, and were more often treated for diabetes. CONCLUSIONS: HT was found highly prevalent in patient with clinical coronary heart disease, mainly in females, and was associated with several cardiovascular risk factors.

• MeSH
• autoantigeny imunologie   MeSH
• autoprotilátky krev   MeSH
• časové faktory MeSH
• dospělí MeSH
• homocystein krev   MeSH
• hypercholesterolemie komplikace   epidemiologie   MeSH
• hypotyreóza krev   komplikace   epidemiologie   MeSH
• jodidperoxidasa imunologie   MeSH
• koronární nemoc etiologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• odds ratio MeSH
• prevalence MeSH
• proteiny vázající železo imunologie   MeSH
• průřezové studie MeSH
• rizikové faktory MeSH
• rozložení podle pohlaví MeSH
• senioři MeSH
• sexuální faktory MeSH
• stupeň závažnosti nemoci MeSH
• thyreotropin krev   MeSH
• von Willebrandův faktor metabolismus   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Názvy látek
• autoantigeny MeSH
• autoprotilátky MeSH
• homocystein MeSH
• jodidperoxidasa MeSH
• proteiny vázající železo MeSH
• thyreotropin MeSH
• TPO protein, human MeSH Prohlížeč
• von Willebrandův faktor MeSH