Hypocholesterolemia is commonly found in critically ill patients; however, the aetiology of this condition remains unclear. Several clinical studies refer to the possible negative impact of haemodilution on cholesterol (CH) metabolism in acute medical conditions. The aim of this study was to examine the serum CH profile (total CH, LDL and HDL CH) during acute gastrointestinal bleeding which is a life-threatening condition characterised by alterations in lipid metabolism. Serum non-CH sterols (lathosterol, squalene, sitosterol and campesterol) concentrations as markers of CH synthesis and CH absorption were measured at the same time. Twenty-four patients with acute upper gastrointestinal bleeding (UGIB) were measured for these parameters over a 6-day period. The control group was 100 healthy blood donors.We found lower plasma levels of total CH (p < 0.001) and LDL CH (p < 0.05) in patients with UGIB than in the control group. The decreased HDL CH plasma levels in patients were not statistically significant. In addition, patients had significantly lower plasma levels of lathosterol, squalene, campesterol and sitosterol (p < 0.05).Our results showed abnormalities not only in the CH plasma profile, but also in plasma concentrations of non-CH sterols. These findings of alterations in both the CH synthesis and absorption process could be a contributory cause of hypocholesterolemia during acute gastrointestinal bleeding. However, further research is necessary.

• MeSH
• akutní nemoc MeSH
• cholesterol krev   MeSH
• ezofageální a žaludeční varixy krev   etiologie   terapie   MeSH
• gastrointestinální endoskopie MeSH
• gastrointestinální krvácení krev   etiologie   terapie   MeSH
• HDL-cholesterol krev   MeSH
• hematemeze krev   terapie   MeSH
• hemodiluce škodlivé účinky   MeSH
• hypercholesterolemie krev   MeSH
• inhibitory protonové pumpy aplikace a dávkování   MeSH
• intravenózní infuze MeSH
• jaterní cirhóza krev   komplikace   terapie   MeSH
• jednotky intenzivní péče MeSH
• kohortové studie MeSH
• kombinovaná terapie MeSH
• LDL-cholesterol krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lypresin aplikace a dávkování   analogy a deriváty   MeSH
• meléna krev   terapie   MeSH
• následné studie MeSH
• omeprazol aplikace a dávkování   MeSH
• parenterální výživa úplná MeSH
• senioři MeSH
• tekutinová terapie MeSH
• terlipresin MeSH
• transfuze erytrocytů MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• cholesterol MeSH
• HDL-cholesterol MeSH
• inhibitory protonové pumpy MeSH
• LDL-cholesterol MeSH
• lypresin MeSH
• omeprazol MeSH
• terlipresin MeSH

Hypocholesterolemia has been investigated as a typical feature of critical illness and is connected with poor prognosis. Crohn's disease is an inflammatory process and is associated with several metabolic disturbances. In recent decades clinical studies have established a link between lipid metabolism and systemic inflammation. In our study we examined the serum profile of cholesterol (total cholesterol, LDL- and HDL-cholesterol) and changes in the cholesterol absorption/synthesis process by determination of plasma non-cholesterol sterol (squalene, lathosterol, campesterol, sitosterol) concentrations. Serum concentrations of total cholesterol, LDL- and HDL-cholesterol and non-cholesterol sterols were evaluated in 24 patients with active Crohn's disease during a period of 28 days. We detected lower serum levels of total cholesterol (P < 0.001), LDL- and HDL-cholesterol (P < 0.05) in the patients with active Crohn's disease than in the control group. In addition, the patients had significantly lower plasma levels of lathosterol (P < 0.001) and higher concentrations of squalene, although without significant differences. A significant decrease of campesterol plasma levels (P < 0.001) was detected, but lower plasma concentrations of sitosterol were without statistical significance. The active phase of Crohn's disease is characterized by altered metabolism of lipids, mainly of cholesterol. Our results show abnormalities in plasma concentrations of non-cholesterol sterols and provide evidence that the process of cholesterol synthesis and absorption is altered in active Crohn's disease.

• MeSH
• cholesterol krev   MeSH
• Crohnova nemoc krev   MeSH
• dospělí MeSH
• HDL-cholesterol krev   MeSH
• intestinální absorpce fyziologie   MeSH
• LDL-cholesterol krev   MeSH
• lidé MeSH
• protein-energetická malnutrice krev   MeSH
• referenční hodnoty MeSH
• steroly krev   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• cholesterol MeSH
• HDL-cholesterol MeSH
• LDL-cholesterol MeSH
• steroly MeSH