Adenosines, endogenous purine nucleosides, appear in the extracellular space under metabolically stressful conditions associated with ischemia, inflammation, and cell damage. Their activity on innate immunity is prevalently inhibitory and can develop both in infectious and neoplastic diseases. During cancer development, tumor cells that release high concentrations of adenosines can impair the function of tumor-infiltrating lymphocytes and assist tumor growth by neo-angiogenesis. We evaluated the influence of A(2) adenosine receptor (A(2)AR) agonist on cytotoxic-cell response comparing human with other mammalian species (rodents, pigs, goats), both in healthy and in cancer conditions. The A(2)AR agonist developed dose-dependent inhibition of the cytotoxic activity of immune effector cells in all studied species. However, variability of the response was observed in relation to the species and the target cells that were used. Altogether, our data indicate that the A(2)AR plays a central role in adenosine-mediated inhibition of immune response to tumors.

• MeSH
• adenosin analogy a deriváty   imunologie   farmakologie   MeSH
• agonisté adenosinového receptoru A2 * MeSH
• buňky NK účinky léků   imunologie   MeSH
• cytotoxicita imunologická účinky léků   MeSH
• hlodavci MeSH
• kozy MeSH
• krysa rodu Rattus MeSH
• kultivované buňky MeSH
• lidé MeSH
• myši inbrední C57BL MeSH
• myši MeSH
• nádory imunologie   MeSH
• potkani Wistar MeSH
• prasata MeSH
• receptory adenosinové A2 imunologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• lidé MeSH
• mužské pohlaví MeSH
• myši MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• adenosin MeSH
• agonisté adenosinového receptoru A2 * MeSH
• N-cyclopropyl adenosine-5'-carboxamide MeSH Prohlížeč
• receptory adenosinové A2 MeSH