Systemic and local cytokine response of young piglets to oral infection with Salmonella enterica serotype Typhimurium
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12879755
DOI
10.1007/bf02931375
Knihovny.cz E-resources
- MeSH
- Cytokines blood metabolism MeSH
- Microscopy, Electron veterinary MeSH
- Enzyme-Linked Immunosorbent Assay veterinary MeSH
- Gastrointestinal Diseases immunology microbiology pathology veterinary MeSH
- Ileum immunology microbiology pathology ultrastructure MeSH
- Lymph Nodes immunology microbiology pathology ultrastructure MeSH
- Swine, Miniature MeSH
- Swine Diseases immunology microbiology pathology MeSH
- Animals, Newborn MeSH
- Swine MeSH
- Salmonella typhimurium growth & development ultrastructure MeSH
- Salmonella Infections, Animal immunology microbiology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cytokines MeSH
One-week-old breast-fed miniature piglets were orally infected either with virulent LT2 strain or with a non-virulent SF1591 rough mutant of Salmonella Typhimurium for 1 d. Both microorganisms were cultivated from mesenteric lymph nodes but not from the blood of infected piglets. Interleukins (IL) 1 beta, 8, 18, tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) were quantified by ELISA in plasma and washes of a terminal part of the small bowel. In plasma, cytokines were mostly missing in non-infected piglets and either missing or low in infected piglets. In the gut of non-infected piglets, IL-1 beta, IL-8 and IL-18 were detected whereas TNF-alpha and IFN-gamma were mostly missing. IFN-gamma levels highly increased (p < 0.05) after infection with nonvirulent salmonellae. The variability of cytokine levels in the gut of suckling piglets is discussed.
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