Systemic and local cytokine response of young piglets to oral infection with Salmonella enterica serotype Typhimurium
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
12879755
DOI
10.1007/bf02931375
Knihovny.cz E-zdroje
- MeSH
- cytokiny krev metabolismus MeSH
- elektronová mikroskopie veterinární MeSH
- ELISA veterinární MeSH
- gastrointestinální nemoci imunologie mikrobiologie patologie veterinární MeSH
- ileum imunologie mikrobiologie patologie ultrastruktura MeSH
- lymfatické uzliny imunologie mikrobiologie patologie ultrastruktura MeSH
- miniaturní prasata MeSH
- nemoci prasat imunologie mikrobiologie patologie MeSH
- novorozená zvířata MeSH
- prasata MeSH
- Salmonella typhimurium růst a vývoj ultrastruktura MeSH
- salmonelová infekce u zvířat imunologie mikrobiologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cytokiny MeSH
One-week-old breast-fed miniature piglets were orally infected either with virulent LT2 strain or with a non-virulent SF1591 rough mutant of Salmonella Typhimurium for 1 d. Both microorganisms were cultivated from mesenteric lymph nodes but not from the blood of infected piglets. Interleukins (IL) 1 beta, 8, 18, tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) were quantified by ELISA in plasma and washes of a terminal part of the small bowel. In plasma, cytokines were mostly missing in non-infected piglets and either missing or low in infected piglets. In the gut of non-infected piglets, IL-1 beta, IL-8 and IL-18 were detected whereas TNF-alpha and IFN-gamma were mostly missing. IFN-gamma levels highly increased (p < 0.05) after infection with nonvirulent salmonellae. The variability of cytokine levels in the gut of suckling piglets is discussed.
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