Nejvíce citovaný článek - PubMed ID 15618047
In the pandemic "Corona Virus Disease 2019" (COVID-19) people with diabetes have a high risk to require ICU admission. The management of diabetes in Intensive Care Unit is always challenging, however, when diabetes is present in COVID-19 the situation seems even more complicated. An optimal glycemic control, avoiding acute hyperglycemia, hypoglycemia and glycemic variability may significantly improve the outcome. In this case, intravenous insulin infusion with continuous glucose monitoring should be the choice. No evidence suggests stopping angiotensin-converting-enzyme inhibitors, angiotensin-renin-blockers or statins, even it has been suggested that they may increase the expression of Angiotensin-Converting-Enzyme-2 (ACE2) receptor, which is used by "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to penetrate into the cells. A real issue is the usefulness of several biomarkers, which have been suggested to be measured during the COVID-19. N-Terminal-pro-Brain Natriuretic-Peptide, D-dimer and hs-Troponin are often increased in diabetes. Their meaning in the case of diabetes and COVID-19 should be therefore very carefully evaluated. Even though we understand that in such a critical situation some of these requests are not so easy to implement, we believe that the best possible action to prevent a worse outcome is essential in any medical act.
- Klíčová slova
- COVID-19, Cardiovascular complications, Diabetes, Intensive Care Unit,
- MeSH
- antihypertenziva terapeutické užití MeSH
- Betacoronavirus patogenita MeSH
- biologické markery krev MeSH
- COVID-19 MeSH
- diabetes mellitus krev diagnóza farmakoterapie mortalita MeSH
- dyslipidemie farmakoterapie mortalita MeSH
- hodnocení rizik MeSH
- hypertenze farmakoterapie mortalita MeSH
- hypoglykemika škodlivé účinky terapeutické užití MeSH
- interakce hostitele a patogenu MeSH
- jednotky intenzivní péče * MeSH
- koronavirové infekce diagnóza mortalita terapie virologie MeSH
- krevní glukóza účinky léků metabolismus MeSH
- lidé MeSH
- pandemie MeSH
- rizikové faktory MeSH
- SARS-CoV-2 MeSH
- statiny terapeutické užití MeSH
- virová pneumonie diagnóza mortalita terapie virologie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- antihypertenziva MeSH
- biologické markery MeSH
- hypoglykemika MeSH
- krevní glukóza MeSH
- statiny MeSH