Vector-borne diseases constitute 17% of all infectious diseases in the world; among the blood-feeding arthropods, ticks transmit the highest number of pathogens. Understanding the interactions between the tick vector, the mammalian host and the pathogens circulating between them is the basis for the successful development of vaccines against ticks or the tick-transmitted pathogens as well as for the development of specific treatments against tick-borne infections. A lot of effort has been put into transcriptomic and proteomic analyses; however, the protein-carbohydrate interactions and the overall glycobiology of ticks and tick-borne pathogens has not been given the importance or priority deserved. Novel (bio)analytical techniques and their availability have immensely increased the possibilities in glycobiology research and thus novel information in the glycobiology of ticks and tick-borne pathogens is being generated at a faster pace each year. This review brings a comprehensive summary of the knowledge on both the glycosylated proteins and the glycan-binding proteins of the ticks as well as the tick-transmitted pathogens, with emphasis on the interactions allowing the infection of both the ticks and the hosts by various bacteria and tick-borne encephalitis virus.

• Klíčová slova
• Anaplasma, Borrelia, Carbohydrate-binding, Glycan, Glycobiology, Host, Lectin, Pathogen, TBEV, Tick,
• MeSH
• Anaplasma patogenita   MeSH
• Borrelia patogenita   MeSH
• glykomika metody   MeSH
• glykosylace MeSH
• interakce hostitele a patogenu fyziologie   MeSH
• klíště mikrobiologie   fyziologie   virologie   MeSH
• lektiny metabolismus   MeSH
• nemoci přenášené klíšťaty patofyziologie   MeSH
• polysacharidy metabolismus   MeSH
• proteomika MeSH
• sacharidy fyziologie   MeSH
• viry klíšťové encefalitidy patogenita   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• lektiny MeSH
• polysacharidy MeSH
• sacharidy MeSH

We investigated the presence of glycoproteins in Borrelia burgdorferi. We did not find any evidence for glycosylation of the major outer membrane proteins OspA and OspB or the structural flagellar proteins FlaB and FlaA. We suggest that glycoproteins present on the surface of B. burgdorferi may be tightly bound culture medium glycoproteins.

• MeSH
• antigeny bakteriální genetika   metabolismus   MeSH
• antigeny povrchové genetika   metabolismus   MeSH
• bakteriální vakcíny genetika   metabolismus   MeSH
• Borrelia burgdorferi genetika   metabolismus   ultrastruktura   MeSH
• elektroforéza v polyakrylamidovém gelu MeSH
• elektronová kryomikroskopie MeSH
• flagelin genetika   metabolismus   MeSH
• glykosylace MeSH
• hmotnostní spektrometrie s elektrosprejovou ionizací MeSH
• lipoproteiny genetika   metabolismus   MeSH
• molekulární sekvence - údaje MeSH
• proteiny vnější bakteriální membrány genetika   metabolismus   MeSH
• sekvence aminokyselin MeSH
• sekvenční homologie aminokyselin MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antigeny bakteriální MeSH
• antigeny povrchové MeSH
• bakteriální vakcíny MeSH
• flaA protein, bacteria MeSH Prohlížeč
• flaB flagellin MeSH Prohlížeč
• flagelin MeSH
• lipoproteiny MeSH
• OspA protein MeSH Prohlížeč
• OspB protein, Borrelia burgdorferi MeSH Prohlížeč
• proteiny vnější bakteriální membrány MeSH

Selected cerebrospinal-fluid (CSF) parameters (intrathecal synthesis of Borrelia-specific antibodies, oligoclonal IgG bands, CSF-to-serum quotient of albumin as a marker of blood-CSF barrier function and cytology) and typical CSF profile in neuroborreliosis were evaluated with the aim of elucidating possible clinical and laboratory similarities of neuroborreliosis (NB) and other neurological diseases (OND). From the cohort of 58 patients (38 diagnosed for NB, 20 with OND) NB patients had positive Borrelia-specific IgG antibodies in 97 % and positive Borrelia-specific IgM antibodies in 55 %; oligoclonal IgG bands were detected in 55%. The blood-CSF barrier was impaired in 89%, positive cytology was detected in 97% of the NB patients. Evaluation of specific intrathecal synthesis improves CSF diagnosis of NB, therefore, a combined CSF analysis has to be considered along with the clinical picture and medical history when formulating the diagnosis of NB.

• MeSH
• Borrelia burgdorferi komplex * imunologie   MeSH
• diferenciální diagnóza MeSH
• hematoencefalická bariéra MeSH
• histocytochemie MeSH
• imunoglobulin G mozkomíšní mok   MeSH
• imunoglobulin M mozkomíšní mok   MeSH
• lidé MeSH
• lymská neuroborelióza mozkomíšní mok   diagnóza   MeSH
• mozkomíšní mok * chemie   cytologie   imunologie   MeSH
• nemoci nervového systému mozkomíšní mok   diagnóza   MeSH
• protilátky bakteriální mozkomíšní mok   MeSH
• sérový albumin mozkomíšní mok   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• imunoglobulin G MeSH
• imunoglobulin M MeSH
• protilátky bakteriální MeSH
• sérový albumin MeSH