1,2-Bis-[2-(5-H/Me/Cl/NO2)-1H-benzimidazolyl]-1,2-ethanediols (L1-L4), 1,4-bis-[2-(5-H/Me/Cl)-1H-benzimidazolyl]-1,2,3,4-butanetetraols (L5-L7) and their complexes with ZnCl2, CdCl2 and HgCl2 were synthesized and antibacterial activity of the compounds was tested toward Staphylococcus aureus, S. epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Proteus mirabilis and antifungal activity against Candida albicans. HgII complexes have a considerably higher antimicrobial activity against all microorganisms. Some HgII complexes show higher antifungal activity than clotrimazole toward C. albicans. Zn2(L3)Cl4, Zn2(L4)Cl4, and Cd(L3)Cl2 were moderately effective against S. aureus and S. epidermidis; Cd(L4)Cl2 exhibited a weak activity only against S. epidermidis.

• MeSH
• Anti-Infective Agents chemical synthesis   chemistry   pharmacology   MeSH
• Bacteria drug effects   MeSH
• Benzimidazoles chemical synthesis   chemistry   pharmacology   MeSH
• Butanes chemistry   pharmacology   MeSH
• Candida albicans drug effects   MeSH
• Ethylene Glycols chemistry   pharmacology   MeSH
• Cadmium chemistry   pharmacology   MeSH
• Ligands MeSH
• Microbial Sensitivity Tests MeSH
• Mercury chemistry   pharmacology   MeSH
• Spectrophotometry, Infrared MeSH
• Metals, Heavy chemistry   pharmacology   MeSH
• Zinc chemistry   pharmacology   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Anti-Infective Agents MeSH
• Benzimidazoles MeSH
• Butanes MeSH
• Ethylene Glycols MeSH
• Cadmium MeSH
• Ligands MeSH
• Mercury MeSH
• Metals, Heavy MeSH
• Zinc MeSH