The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and associated metabolic disturbances. Multiple quantitative trait loci associated with hemodynamic and metabolic parameters have been mapped in the SHR. Recently, it has become possible to identify some of the specific quantitative trait gene (QTG) variants that underlie quantitative trait loci linked to complex cardiovascular and metabolic traits in SHR related strains. Recombinant inbred strains derived from SHR and Brown Norway progenitors, together with SHR congenic and transgenic strains, have proven useful for establishing the identity of several QTGs in SHR models. It is anticipated that the combined use of linkage analyses and gene expression profiles, together with the recently available genome sequences of both the SHR and Brown Norway strains and new methods for manipulating the rat genome, will soon accelerate progress in identifying QTGs for complex traits in SHR-related strains.

• MeSH
• exprese genu MeSH
• inbrední kmeny potkanů genetika   MeSH
• krysa rodu Rattus MeSH
• kvantitativní znak dědičný MeSH
• lokus kvantitativního znaku genetika   MeSH
• mapování chromozomů MeSH
• mitochondriální DNA genetika   MeSH
• potkani inbrední SHR genetika   MeSH
• potkani transgenní MeSH
• technika přenosu genů MeSH
• transposasy MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Research Support, N.I.H., Extramural MeSH
• Názvy látek
• mitochondriální DNA MeSH
• transposasy MeSH