Searching for novel antimicrobial agents still represents a current topic in medicinal chemistry. In this study, the synthesis and analytical data of eighteen salicylanilide esters with 4-(trifluoromethyl)benzoic acid are presented. They were assayed in vitro as potential antimycotic agents against eight fungal strains, along with their parent salicylanilides. The antifungal activity of the presented derivatives was not uniform and moulds showed a higher susceptibility with minimum inhibitory concentrations (MIC) ≥ 0.49 µmol/L than yeasts (MIC ≥ 1.95 µmol/L). However, it was not possible to evaluate a range of 4-(trifluoromethyl)benzoates due to their low solubility. In general, the most active salicylanilide was N-(4-bromophenyl)-4-chloro-2-hydroxybenzamide and among esters, the corresponding 2-(4-bromophenylcarbamoyl)-5-chlorophenyl 4-(trifluoromethyl) benzoate exhibited the lowest MIC of 0.49 µmol/L. However, the esterification of salicylanilides by 4-(trifluoromethyl)benzoic acid did not result unequivocally in a higher antifungal potency.

• MeSH
• Absidia účinky léků   MeSH
• antifungální látky chemická syntéza   farmakologie   MeSH
• Aspergillus fumigatus účinky léků   MeSH
• benzoáty chemická syntéza   farmakologie   MeSH
• Candida účinky léků   MeSH
• esterifikace MeSH
• estery MeSH
• mikrobiální testy citlivosti MeSH
• salicylanilidy chemická syntéza   farmakologie   MeSH
• toluen analogy a deriváty   chemie   MeSH
• Trichophyton účinky léků   MeSH
• Trichosporon účinky léků   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• 4-(trifluoromethyl)benzoic acid MeSH Prohlížeč
• antifungální látky MeSH
• benzoáty MeSH
• estery MeSH
• salicylanilidy MeSH
• toluen MeSH