Most cited article - PubMed ID 17702458
Effect of protein kinase inhibitors on protein phosphorylation and germination of aerial spores from Streptomyces coelicolor
This review summarizes the main results obtained in the fields of general and molecular microbiology and microbial genetics at the Institute of Microbiology of the Academy of Sciences of the Czech Republic (AS CR) [formerly Czechoslovak Academy of Sciences (CAS)] over more than 50 years. Contribution of the founder of the Institute, academician Ivan Málek, to the introduction of these topics into the scientific program of the Institute of Microbiology and to further development of these studies is also included.
- MeSH
- Academies and Institutes history MeSH
- History, 20th Century MeSH
- Genetics, Microbial history MeSH
- Molecular Biology history MeSH
- Check Tag
- History, 20th Century MeSH
- Publication type
- Journal Article MeSH
- Historical Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Geographicals
- Czech Republic MeSH
We present the results of analysis of membrane phosphoproteomes from individual morphological stages of Streptomyces coelicolor that reflect developmentally dependent heterogeneity and phosphorylation of intrinsic and externally added purified Strepomyces aureofaciens EF-Tu. Fast growing nonpathogenic Mycobacterium smegmatis was used as a non-differentiating actinomycetes comparative model. Streptomycetes membrane fraction was found to contain protein kinase(s) catalyzing phosphorylation of both its own and an externally added EF-Tu, whereas Mycobacterium membrane fraction contains protein kinase phosphorylating only its own EF-Tu.
- MeSH
- Cell Membrane chemistry enzymology metabolism MeSH
- Peptide Elongation Factor Tu isolation & purification metabolism MeSH
- Phosphorylation MeSH
- Mycobacterium smegmatis chemistry enzymology metabolism MeSH
- Protein Processing, Post-Translational * MeSH
- Protein Kinases isolation & purification metabolism MeSH
- Streptomyces chemistry enzymology metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Peptide Elongation Factor Tu MeSH
- Protein Kinases MeSH
