Although gastrointestinal toxicity is one of the most common side effects of anticancer therapy, the diagnosis and assessment of this toxicity still depend mostly on anamnestic data. Measurement of intestinal permeability is one of potential methods of non-invasive laboratory evaluation of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability, vitamin A absorption, serum alpha-tocopherol, and urinary neopterin in patients with rectal carcinoma treated with chemoradiation. We have studied intestinal permeability, vitamin A absorption, serum alpha-tocopherol, and urinary neopterin in 17 patients with rectal carcinoma treated with chemoradiation. Urinary lactulose, mannitol, and xylose were measured by capillary gas chromatography, and serum alpha-tocopherol, retinol, retinyl esters, and urinary neopterin were determined by high-performance liquid chromatography. Lactulose/mannitol ratio was increased 5 and 6 weeks after the start of the treatment. Serum alpha-tocopherol was decreased significantly throughout the course of treatment, but no significant changes were observed in postprandial serum concentrations of retinyl esters or in the concentrations of urinary neopterin. A correlation was observed between baseline parameters of intestinal permeability and urinary neopterin. The measurement of intestinal permeability using the lactulose/mannitol test may represent a sensitive tool in the detection of changes associated with chemoradiation in patients with rectal carcinoma. The therapy is also associated with a decrease of alpha-tocopherol.

• MeSH
• adenokarcinom farmakoterapie   imunologie   metabolismus   radioterapie   MeSH
• alfa-tokoferol krev   MeSH
• antioxidancia metabolismus   MeSH
• chromatografie plynová MeSH
• dietní sacharidy farmakokinetika   MeSH
• diterpeny MeSH
• fluoruracil škodlivé účinky   terapeutické užití   MeSH
• intestinální absorpce * účinky léků   účinky záření   MeSH
• kombinovaná terapie MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory rekta farmakoterapie   imunologie   metabolismus   radioterapie   MeSH
• neopterin moč   MeSH
• protinádorové antimetabolity škodlivé účinky   terapeutické užití   MeSH
• retinylestery MeSH
• sacharidy moč   MeSH
• senioři MeSH
• vitamin A aplikace a dávkování   analogy a deriváty   krev   farmakokinetika   MeSH
• vysokoenergetická radioterapie škodlivé účinky   MeSH
• vysokoúčinná kapalinová chromatografie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• alfa-tokoferol MeSH
• antioxidancia MeSH
• dietní sacharidy MeSH
• diterpeny MeSH
• fluoruracil MeSH
• neopterin MeSH
• protinádorové antimetabolity MeSH
• retinol palmitate MeSH Prohlížeč
• retinylestery MeSH
• sacharidy MeSH
• vitamin A MeSH