Although gastrointestinal toxicity is one of the most common side effects of anticancer therapy, the diagnosis and assessment of this toxicity still depend mostly on anamnestic data. Measurement of intestinal permeability is one of potential methods of non-invasive laboratory evaluation of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability, vitamin A absorption, serum alpha-tocopherol, and urinary neopterin in patients with rectal carcinoma treated with chemoradiation. We have studied intestinal permeability, vitamin A absorption, serum alpha-tocopherol, and urinary neopterin in 17 patients with rectal carcinoma treated with chemoradiation. Urinary lactulose, mannitol, and xylose were measured by capillary gas chromatography, and serum alpha-tocopherol, retinol, retinyl esters, and urinary neopterin were determined by high-performance liquid chromatography. Lactulose/mannitol ratio was increased 5 and 6 weeks after the start of the treatment. Serum alpha-tocopherol was decreased significantly throughout the course of treatment, but no significant changes were observed in postprandial serum concentrations of retinyl esters or in the concentrations of urinary neopterin. A correlation was observed between baseline parameters of intestinal permeability and urinary neopterin. The measurement of intestinal permeability using the lactulose/mannitol test may represent a sensitive tool in the detection of changes associated with chemoradiation in patients with rectal carcinoma. The therapy is also associated with a decrease of alpha-tocopherol.

Department of Oncology and Radiotherapy Charles University Medical School and Teaching Hospital Hradec Králové Czech Republic

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N Engl J Med. 2004 Oct 21;351(17):1731-40 PubMed

Atherosclerosis. 1991 Aug;89(2-3):203-8 PubMed

Cancer Res. 1986 Feb;46(2):950-5 PubMed

Free Radic Biol Med. 1996;20(7):979-83 PubMed

Chemotherapy. 2005 Oct;51(6):336-8 PubMed

J Clin Gastroenterol. 2001 Mar;32(3):228-30 PubMed

Am J Physiol Gastrointest Liver Physiol. 2001 Jan;280(1):G95-G103 PubMed

Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):117-23 PubMed

Clin Nutr. 2002 Apr;21(2):161-4 PubMed

Ann Clin Biochem. 2004 Mar;41(Pt 2):138-41 PubMed

J Clin Invest. 1996 Jul 15;98(2):386-94 PubMed

J Natl Cancer Inst. 2000 Mar 1;92(5):388-96 PubMed

J Sep Sci. 2006 Nov;29(16):2485-93 PubMed

J Nutr. 2001 May;131(5):1405-8 PubMed

Anticancer Res. 2007 Nov-Dec;27(6C):4397-401 PubMed

J Cancer Res Clin Oncol. 2001 May;127(5):314-8 PubMed

Atherosclerosis. 1994 Apr;106(2):263-71 PubMed

J Clin Oncol. 2003 Jul 1;21(13):2545-50 PubMed

Br J Nutr. 2005 Feb;93(2):153-74 PubMed

Anticancer Res. 2008 Jul-Aug;28(4C):2389-96 PubMed

Gastroenterology. 1995 May;108(5):1566-81 PubMed

Adv Clin Chem. 1989;27:81-141 PubMed

Am J Clin Nutr. 2004 Jun;79(6):1029-36 PubMed

Int J Biol Markers. 2006 Jul-Sep;21(3):190-8 PubMed

J Am Coll Nutr. 2001 Dec;20(6):637-42 PubMed

Am J Clin Oncol. 2008 Dec;31(6):580-4 PubMed

J Clin Gastroenterol. 2002 Apr;34(4):385-96 PubMed

Am J Clin Nutr. 2002 Dec;76(6):1358-66 PubMed

Int J Gynecol Cancer. 2006 Jan-Feb;16(1):240-52 PubMed

Dig Dis Sci. 2002 Jul;47(7):1480-91 PubMed

Circulation. 1997 Feb 18;95(4):1062-71 PubMed

J Intern Med. 2000 Nov;248(5):377-86 PubMed

Am J Clin Nutr. 2000 Jul;72(1):181-9 PubMed

Nutrition. 2000 Jun;16(6):425-8 PubMed

Nutrition. 1999 Jul-Aug;15(7-8):546-9 PubMed

Am J Clin Nutr. 1992 Apr;55(4):857-64 PubMed

Scand J Gastroenterol Suppl. 1997;223:70-8 PubMed

Anal Chim Acta. 2006 Jul 28;573-574:267-72 PubMed

J Clin Oncol. 2003 Mar 1;21(5):927-31 PubMed