Background. Food protein-induced proctitis/proctocolitis (FPIP) is the most common noninfectious colitis in children in the first year of life. Along with the overall clinical symptoms, diarrhoea and rectal bleeding are the main manifestations of the disease. There is no routine noninvasive test that would be specific for this type of colitis. The aim of our study was to find a noninvasive laboratory test or tests that may be helpful in differential diagnosis of food protein-induced proctitis/proctocolitis. Methods. ANA, ANCA, ASCA, a-EMA, a-tTg, specific IgE, total IgE, IgG, IgA, IgM, and concentration of serum calprotectin were measured in a group of 25 patients with colitis and 18 children with other diagnoses. Results. Atypical-pANCA antibodies of IgG isotype were detected in the sera of 24 patients by the method of indirect immunofluorescence, and 5 patients showed also the positivity of IgA isotype. In control samples these autoantibodies were not detected. Other autoantibodies were not demonstrated in either patient or control group. Conclusions. Of the parameters tested in noninfectious colitis, atypical-pANCA on ethanol-fixed granulocytes appears to be a suitable serological marker of food protein-induced proctitis/proctocolitis and suggests a possible involvement of an autoimmune mechanisms in the pathogenesis of this disease.

• MeSH
• Autoimmunity MeSH
• Autoantibodies immunology   MeSH
• Biomarkers MeSH
• Dietary Proteins immunology   MeSH
• Enzyme-Linked Immunosorbent Assay MeSH
• Immunoglobulin A blood   immunology   MeSH
• Immunoglobulin G blood   immunology   MeSH
• Immunoglobulin Isotypes blood   immunology   MeSH
• Infant MeSH
• Humans MeSH
• Infant, Newborn MeSH
• Child, Preschool MeSH
• Prevalence MeSH
• Proctocolitis diagnosis   immunology   MeSH
• Antibodies, Antineutrophil Cytoplasmic immunology   MeSH
• Antibody Specificity immunology   MeSH
• Case-Control Studies MeSH
• Check Tag
• Infant MeSH
• Humans MeSH
• Male MeSH
• Infant, Newborn MeSH
• Child, Preschool MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Autoantibodies MeSH
• Biomarkers MeSH
• Dietary Proteins MeSH
• Immunoglobulin A MeSH
• Immunoglobulin G MeSH
• Immunoglobulin Isotypes MeSH
• Antibodies, Antineutrophil Cytoplasmic MeSH